Interpolyelectrolyte complexes of a biguanide cationic polyelectrolyte: formation of core/corona nanoparticles with double-hydrophilic diblock polyanion†

IF 2.9 3区 化学 Q3 CHEMISTRY, PHYSICAL
Soft Matter Pub Date : 2024-11-18 DOI:10.1039/D4SM00851K
Patricia Montes, Tania Chopra, Rafał Konefał, Pavla Hájovská, Igor Lacík, Vladimír Raus, Miroslav Šlouf, Mariusz Uchman and Miroslav Štěpánek
{"title":"Interpolyelectrolyte complexes of a biguanide cationic polyelectrolyte: formation of core/corona nanoparticles with double-hydrophilic diblock polyanion†","authors":"Patricia Montes, Tania Chopra, Rafał Konefał, Pavla Hájovská, Igor Lacík, Vladimír Raus, Miroslav Šlouf, Mariusz Uchman and Miroslav Štěpánek","doi":"10.1039/D4SM00851K","DOIUrl":null,"url":null,"abstract":"<p >Biguanide-based cationic polyelectrolytes are used as key components of interpolyelectrolyte complexes bolstering alginate hydrogel microcapsules employed in cell therapies. Nevertheless, electrostatic complexation of these unique polycations has not been studied before. In this study, the interaction between biguanide condensates and anionic polyelectrolytes with carboxylate groups was studied on a model system of a metformin condensate (MFC) and an anionic diblock polyelectrolyte poly(methacrylic acid)-<em>block</em>-poly(ethylene oxide) (PMAA–PEO). The formation of MFC/PMAA–PEO core–corona nanoparticles was followed by static, dynamic and electrophoretic light scattering and by isothermal titration calorimetry and their internal structure was investigated by small angle neutron scattering and cryogenic transmission electron microscopy. It was found that the aggregation of PMAA–PEO chains induced by MFC occurred at much lower MFC/PMAA–PEO ratios that would correspond to the isoelectric point, thus yielding strongly negatively charged nanoparticles, suggesting the role of specific (non-electrostatic) interactions in the stabilization of the complex between PMAA and MFC.</p>","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 47","pages":" 9475-9482"},"PeriodicalIF":2.9000,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/sm/d4sm00851k?page=search","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Soft Matter","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/sm/d4sm00851k","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0

Abstract

Biguanide-based cationic polyelectrolytes are used as key components of interpolyelectrolyte complexes bolstering alginate hydrogel microcapsules employed in cell therapies. Nevertheless, electrostatic complexation of these unique polycations has not been studied before. In this study, the interaction between biguanide condensates and anionic polyelectrolytes with carboxylate groups was studied on a model system of a metformin condensate (MFC) and an anionic diblock polyelectrolyte poly(methacrylic acid)-block-poly(ethylene oxide) (PMAA–PEO). The formation of MFC/PMAA–PEO core–corona nanoparticles was followed by static, dynamic and electrophoretic light scattering and by isothermal titration calorimetry and their internal structure was investigated by small angle neutron scattering and cryogenic transmission electron microscopy. It was found that the aggregation of PMAA–PEO chains induced by MFC occurred at much lower MFC/PMAA–PEO ratios that would correspond to the isoelectric point, thus yielding strongly negatively charged nanoparticles, suggesting the role of specific (non-electrostatic) interactions in the stabilization of the complex between PMAA and MFC.

Abstract Image

双胍阳离子聚电解质的聚电解质间复合物:与双亲水二嵌段聚阴离子形成核心/电晕纳米粒子。
基于双胍的阳离子聚电解质被用作间电解质复合物的关键成分,以增强细胞疗法中使用的海藻酸盐水凝胶微胶囊。然而,这些独特的多阳离子的静电络合以前还没有研究过。本研究以二甲双胍缩合物(MFC)和阴离子二嵌段聚电解质聚(甲基丙烯酸)-嵌段-聚(环氧乙烷)(PMAA-PEO)为模型系统,研究了双胍缩合物与带有羧基的阴离子聚电解质之间的相互作用。通过静态、动态和电泳光散射以及等温滴定量热法跟踪了 MFC/PMAA-PEO 核心电晕纳米粒子的形成过程,并通过小角中子散射和低温透射电子显微镜研究了其内部结构。研究发现,在 MFC 诱导的 PMAA-PEO 链聚集过程中,MFC/PMAA-PEO 比值远低于等电点,因此产生了带强负电荷的纳米颗粒,这表明特定(非静电)相互作用在稳定 PMAA 和 MFC 之间的复合物方面发挥了作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Soft Matter
Soft Matter 工程技术-材料科学:综合
CiteScore
6.00
自引率
5.90%
发文量
891
审稿时长
1.9 months
期刊介绍: Soft Matter is an international journal published by the Royal Society of Chemistry using Engineering-Materials Science: A Synthesis as its research focus. It publishes original research articles, review articles, and synthesis articles related to this field, reporting the latest discoveries in the relevant theoretical, practical, and applied disciplines in a timely manner, and aims to promote the rapid exchange of scientific information in this subject area. The journal is an open access journal. The journal is an open access journal and has not been placed on the alert list in the last three years.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信