Arterial Occlusive Events in a Patient With Chronic Myeloid Leukemia Treated With Ponatinib

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL

Clinical Case Reports Pub Date : 2024-11-19 DOI:10.1002/ccr3.9597

Osamu Imataki, Makiko Uemura

引用次数: 0

Abstract

Arterial occlusive events (AOE) are rare adverse event in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitor such as ponatinib. We treated a 47-year-old woman with chronic myeloid leukemia. She was failed to achieve optimal molecular response in prior two lines tyrosine kinase inhibitors treatment (dasatinib and bosutinib) for first 30 months. Finally, she was treated with ponatinib and achieve complete molecular remission in 28 months. However, she was suffered from AOE, in bilateral stenosis of the middle cerebral arteries. The patient's responsible vascular lesions of AOE were atypical site rather than usually affected lesions in common arteriosclerosis.

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一名接受泊纳替尼治疗的慢性髓性白血病患者的动脉闭塞事件

动脉闭塞事件（AOE）是使用酪氨酸激酶抑制剂（如泊纳替尼）治疗慢性髓性白血病患者的罕见不良反应。我们治疗了一名47岁的慢性髓性白血病女性患者。她在接受两线酪氨酸激酶抑制剂（达沙替尼和博苏替尼）治疗的前30个月中未能获得最佳分子反应。最后，她接受了泊纳替尼治疗，并在 28 个月后获得完全分子缓解。然而，她又患上了双侧大脑中动脉狭窄的 AOE。与常见的动脉硬化症相比，患者的AOE血管病变部位并不典型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Case Reports MEDICINE, GENERAL & INTERNAL-

自引率

14.30%

发文量

1268

审稿时长

13 weeks

期刊介绍： Clinical Case Reports is different from other case report journals. Our aim is to directly improve global health and increase clinical understanding using case reports to convey important best practice information. We welcome case reports from all areas of Medicine, Nursing, Dentistry, and Veterinary Science and may include: -Any clinical case or procedure which illustrates an important best practice teaching message -Any clinical case or procedure which illustrates the appropriate use of an important clinical guideline or systematic review. As well as: -The management of novel or very uncommon diseases -A common disease presenting in an uncommon way -An uncommon disease masquerading as something more common -Cases which expand understanding of disease pathogenesis -Cases where the teaching point is based on an error -Cases which allow us to re-think established medical lore -Unreported adverse effects of interventions (drug, procedural, or other).