Exploring myostatin’s role and potential applications in fisheries and aquaculture: a review

IF 2.2 3区农林科学 Q2 FISHERIES

Aquaculture International Pub Date : 2024-11-21 DOI:10.1007/s10499-024-01700-3

Priyanka, Shubham Kashyap, Umesh, Kavita Verma, Mahender Singh, Neelam Yadav

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Abstract

The growth and development of muscles in vertebrates are regulated by myostatin and has garnered significant attention in aquaculture and fisheries due to its potential applications in increasing fish and shellfish production. The myostatin (MSTN) gene controls skeletal muscle development in all vertebrates. This strategy can increase fish growth and production of fish biomass. Higher concentrations of myostatin inhibit muscle growth, whereas lower concentrations accelerate it. Follistatin, a protein released by the liver cells in response to extreme physical activity, conquers myostatin. Therefore, there is significant interest in creating novel medications that block myostatin signaling to increase muscle mass in severe muscular atrophy. This review article provides valuable information on the significance of MSTN in enhancing the efficiency of aquaculture cultivation and it acts as an inhibitor of myogenesis by suppressing the proliferation and differentiation of myoblasts. Manipulating (inhibiting) myostatin expression has become a probable approach in fisheries to increase the muscle mass of fish, resulting in higher yields of edible sections in aquatic species used for aquaculture. This strategy may resolve the increasing global demand and supply for high-quality protein sources.

Graphical Abstract

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探索肌肽在渔业和水产养殖中的作用和潜在应用：综述

脊椎动物肌肉的生长和发育受肌节蛋白的调控，由于肌节蛋白在提高鱼类和贝类产量方面的潜在应用，肌节蛋白在水产养殖和渔业领域引起了极大的关注。肌节蛋白（MSTN）基因控制着所有脊椎动物骨骼肌的发育。这种策略可以提高鱼类的生长速度和鱼类生物量的产量。高浓度的肌节蛋白会抑制肌肉生长，而低浓度的肌节蛋白则会加速肌肉生长。肝脏细胞在剧烈运动时释放的一种蛋白质 Follistatin 可以战胜肌节蛋白。因此，人们对开发新型药物以阻断肌生长抑素信号传导，从而增加重症肌肉萎缩患者的肌肉质量产生了浓厚的兴趣。这篇综述文章提供了有关 MSTN 在提高水产养殖效率方面的重要意义的宝贵信息，MSTN 通过抑制肌母细胞的增殖和分化而成为肌生成的抑制剂。操纵（抑制）肌生长蛋白的表达已成为渔业中增加鱼类肌肉质量的一种可能方法，从而提高用于水产养殖的水生物种可食部分的产量。这一策略可以解决全球对优质蛋白质来源日益增长的需求和供应问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aquaculture International 农林科学-渔业

CiteScore

5.10

自引率

6.90%

发文量

204

审稿时长

1.0 months

期刊介绍： Aquaculture International is an international journal publishing original research papers, short communications, technical notes and review papers on all aspects of aquaculture. The Journal covers topics such as the biology, physiology, pathology and genetics of cultured fish, crustaceans, molluscs and plants, especially new species; water quality of supply systems, fluctuations in water quality within farms and the environmental impacts of aquacultural operations; nutrition, feeding and stocking practices, especially as they affect the health and growth rates of cultured species; sustainable production techniques; bioengineering studies on the design and management of offshore and land-based systems; the improvement of quality and marketing of farmed products; sociological and societal impacts of aquaculture, and more. This is the official Journal of the European Aquaculture Society.