Effects of Fractionated Proton Irradiation in Combination with 1-β-D-Arabinofuranosylcytosine on B16 Murine Melanoma In Vivo

IF 0.4 Q4 PHYSICS, PARTICLES & FIELDS

Physics of Particles and Nuclei Letters Pub Date : 2024-11-22 DOI:10.1134/S1547477124701784

I. A. Zamulaeva, O. N. Matchuk, E. I. Selivanova, V. A. Mosina, M. R. Abramova, V. O. Saburov, S. N. Koryakin, S. A. Ivanov, A. D. Kaprin, A. V. Boreyko, V. N. Chausov, E. A. Krasavin

引用次数: 0

Abstract

This study is a search for means of sensitization of malignant tumors to proton radiation among DNA damage repair inhibitors. It has been found that in the presence of 1-β-D-arabinofuranosylcytosine (AraC), five weekly proton irradiations at a total focal dose of 50 Gy lead to a more pronounced inhibition of B16 murine melanoma growth than the same irradiation without AraC (p < 0.05 ). This effect, associated with a decrease in the proliferative activity of cells in the general population and a decrease in the number of cancer stem cells specifically in the AraC+Protons group, is promising for further improvement of proton radiotherapy.

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分段质子辐照联合 1-β-D-Arabinofuranosylcytosine 对体内 B16 小鼠黑色素瘤的影响

这项研究是在 DNA 损伤修复抑制剂中寻找使恶性肿瘤对质子辐射敏感的方法。研究发现，在存在 1-β-D-arabinofuranosylcytosine (AraC) 的情况下，每周五次总病灶剂量为 50 Gy 的质子辐照对 B16 小鼠黑色素瘤生长的抑制作用比不含 AraC 的相同辐照更明显（p < 0.05）。这种效应与AraC+Protons组一般细胞的增殖活性降低和癌症干细胞数量减少有关，有望进一步改善质子放疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physics of Particles and Nuclei Letters PHYSICS, PARTICLES & FIELDS-

CiteScore

0.80

自引率

20.00%

发文量

108

期刊介绍： The journal Physics of Particles and Nuclei Letters, brief name Particles and Nuclei Letters, publishes the articles with results of the original theoretical, experimental, scientific-technical, methodological and applied research. Subject matter of articles covers: theoretical physics, elementary particle physics, relativistic nuclear physics, nuclear physics and related problems in other branches of physics, neutron physics, condensed matter physics, physics and engineering at low temperatures, physics and engineering of accelerators, physical experimental instruments and methods, physical computation experiments, applied research in these branches of physics and radiology, ecology and nuclear medicine.