Cyclic amine ring expansion

IF 19.2 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nature chemistry Pub Date : 2024-11-21 DOI:10.1038/s41557-024-01674-y

Jack M. Wootton, William P. Unsworth

引用次数: 0

Abstract

Aza-heterocycles with rings of more than 6 members are underrepresented in medicinal chemistry owing to challenges with their synthesis. Now, the conversion of 5- and 6-membered saturated cyclic amines into 7- and 8-membered aza-heterocycles can be achieved via a ring expansion cascade reaction.

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环胺扩环

在药物化学中，具有 6 个以上环的氮杂环由于合成困难而代表性不足。现在，可以通过扩环级联反应将 5 元和 6 元饱和环胺转化为 7 元和 8 元的氮杂环。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature chemistry 化学-化学综合

CiteScore

29.60

自引率

1.40%

发文量

226

审稿时长

1.7 months

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