An enantioselective HAT for diols

IF 42.8 1区化学 Q1 CHEMISTRY, PHYSICAL

Nature Catalysis Pub Date : 2024-11-21 DOI:10.1038/s41929-024-01270-w

Francesco Zamberlan

引用次数: 0

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二元醇的对映选择性 HAT

研究小组探索了催化剂如何在光催化剂1,2,3,5-四（咔唑-9-基）-4,6-二氰基苯（4CzIPN）和蓝光照射下，在顺式-1,2-环己二醇上生成自由基中间体，该中间体可被作为氢原子供体的1-十二硫醇捕获，生成反式-1,2-环己二醇。该反应对不同大小、具有融合环或带有丙酮、酯或苄基的环状二元醇具有耐受性；它还成功地应用于无环状二元醇，如中-己烷-3,4-二醇、中-1,3-二醇和戊烷-2,4-二醇。研究小组还证明，催化剂可以控制丙烯酰胺或乙烯基砜与二元醇基质上生成的自由基进行 Giese 加成时的对映体选择。机理研究证实，光激发的 4CzIPN 会被催化剂淬灭，产生的自由基阳离子会使二元醇发生非对称反应，形成自由基中间体，从而使反应处于动力学控制之下。该中间体经过硫醇的非选择性氢原子传递，生成手性二元醇。

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来源期刊

Nature Catalysis Chemical Engineering-Bioengineering

CiteScore

52.10

自引率

1.10%

发文量

140

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