Rechargeable Afterglow Superclusters for NIR-Excitable Repetitive Phototherapy

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2024-11-21 DOI:10.1021/acs.nanolett.4c04719

Lulu Yue, Yilin Liu, Jing Wang, Yihan Wu, Jinliang Liu, Zhen Zhang, Yong Zhang, Xiaohui Zhu

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引用次数: 0

Abstract

Afterglow luminescence has attracted increasing attention due to its prolonged emission, reduced autofluorescence, and minimized photodamage. However, persistent luminescence typically requires high-energy excitation (e.g., ultraviolet and visible light), which has limited tissue penetration. Herein, we have developed a one-pot surface segregation strategy to construct NIR-excitable afterglow superclusters (UCZG-SCs) by modularly assembling spinel-phase afterglow nanoparticles (Zn_1.1Ga_1.8Ge_0.1O₄:Cr³⁺) and hexagonal-phase upconversion nanoparticles (NaYF₄:Yb,Tm@NaLuF₄:Y). Since the proposed methodology does not require crystal lattice similarity, it enables fabrication of various NIR-excitable persistent superclusters with great flexibility in size, composition, and luminescent profiles. As a proof of concept, an injectable persistent implant is established by embedding UCZG-SCs in the oleosol of poly(lactic-co-glycolic acid)/N-methylpyrrolidone, which serves as an inner-body lamp to excite photosensitizers for photodynamic therapy. With its excellent charging–recharging stability, a repetitive phototherapy under periodic 980 nm light illumination is accomplished, which significantly improves phototherapeutic efficiency and restrains tumor growth.

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用于近红外可激发重复光疗的可充电余辉超簇

余辉发光因其发射时间长、自发荧光少、光损伤小等优点而受到越来越多的关注。然而，持续发光通常需要高能激发（如紫外线和可见光），而这对组织的穿透力有限。在此，我们开发了一种单锅表面分离策略，通过模块化组装尖晶石相余辉纳米粒子（Zn1.1Ga1.8Ge0.1O4:Cr3+）和六方相上转换纳米粒子（NaYF4:Yb,Tm@NaLuF4:Y）来构建近红外可激发余辉超簇（UCZG-SCs）。由于所提出的方法不需要晶格相似性，因此能够制造出各种可激发近红外的持久超簇，在尺寸、组成和发光曲线方面具有极大的灵活性。作为概念验证，通过将 UCZG-SCs 嵌入聚（乳酸-共-乙醇酸）/N-甲基吡咯烷酮的油溶胶中，建立了一种可注射的持久性植入物，该植入物可作为激发光敏剂的体内灯，用于光动力疗法。由于其充电-放电稳定性极佳，可在周期性 980 纳米光照射下实现重复光疗，从而显著提高光疗效率并抑制肿瘤生长。

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.