Hydrophilic-lipophilic balance copolymer composite nanofiber as an adsorbent for online solid phase extraction of three estrogens from water samples with column-switching prior to high-performance liquid chromatography

IF 5.7 2区化学 Q1 CHEMISTRY, ANALYTICAL

Analytica Chimica Acta Pub Date : 2024-11-21 DOI:10.1016/j.aca.2024.343456

X.U. Tong, X.U. Ke, FANG Zhong Ze, C.H.E.N. LiQin

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引用次数: 0

Abstract

Background

In recent years, the increasing accumulation of estrogen pollutants in the environment has raised concerns about their impact on human health, necessitating the development of highly sensitive detection methods for trace pollutant enrichment and analysis in environmental samples. Online pretreatment detection technology offers significant advantages over conventional offline techniques, including high automation, minimal human intervention, and improved efficiency. However, the key to successful implementation lies in the advancement of novel adsorbent materials

Results

Herein, we present a novel adsorbent material called polyacrylonitrile-hydrophilic-lipophilic balanced copolymer (PAN-HLB) composite nanofiber prepared via electrospinning for efficient online packed fiber solid phase extraction (PFSPE) of three estrogens from water samples. A rapid and highly sensitive online PFSPE-HPLC-FLD method was developed for the quantification of 17 β-Estradiol (E2), Estriol (E3), and 17-ethinylestradiol (EE2). The curves of the target analytes were prepared with good correlation coefficient values (r² > 0.9900) in the range of 0.1-2 ng/mL. The limit of detection (S/N=3) was 0.05 ng/mL, the limit of quantitation (S/N=10) is 0.1 ng/mL. The recoveries of three estrogens were 94.0%∼110.3%, and the precisions (RSD) were less than 5%. The online PFSPE column, packed with the PAN-HLB composite nanofiber, exhibits exceptional stability and can be effectively reused for a minimum of 100 cycles.

Significance

This study presents the successful preparation of PAN-HLB composite nanofiber for the first time, demonstrating their efficacy as an innovative online pretreatment adsorbent. The proposed online pretreatment and detection approach offers remarkable benefits in terms of sensitivity, labor-saving, and cost-effectiveness that make it highly suitable for practical water sample analysis.

Abstract Image

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亲水亲油平衡共聚物复合纳米纤维作为吸附剂，用于在线固相萃取水样中的三种雌激素，并在高效液相色谱法之前进行柱切换

背景近年来，雌激素污染物在环境中的积累日益增多，引发了人们对其对人体健康影响的关注，因此有必要开发高灵敏度的检测方法，用于富集和分析环境样品中的痕量污染物。与传统的离线技术相比，在线预处理检测技术具有自动化程度高、人工干预少、效率高等显著优势。然而，成功实施的关键在于新型吸附材料的进步。结果在此，我们介绍了一种通过电纺丝制备的新型吸附材料--聚丙烯腈-亲水-亲油平衡共聚物（PAN-HLB）复合纳米纤维，用于高效在线填充纤维固相萃取（PFSPE）水样中的三种雌激素。建立了一种快速、高灵敏的在线PFSPE-HPLC-FLD方法，用于定量检测17 β-雌二醇（E2）、雌三醇（E3）和17-炔雌醇（EE2）。所制备的目标分析物曲线在 0.1-2 ng/mL 范围内具有良好的相关系数（r2 > 0.9900）。检测限（S/N=3）为 0.05 纳克/毫升，定量限（S/N=10）为 0.1 纳克/毫升。三种雌激素的回收率为94.0%∼110.3%，精密度（RSD）小于5%。本研究首次成功制备了PAN-HLB复合纳米纤维，证明了其作为创新在线预处理吸附剂的功效。所提出的在线预处理和检测方法在灵敏度、省力和成本效益等方面具有显著优势，非常适合实际水样分析。

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来源期刊

Analytica Chimica Acta 化学-分析化学

CiteScore

10.40

自引率

6.50%

发文量

1081

审稿时长

38 days

期刊介绍： Analytica Chimica Acta has an open access mirror journal Analytica Chimica Acta: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Analytica Chimica Acta provides a forum for the rapid publication of original research, and critical, comprehensive reviews dealing with all aspects of fundamental and applied modern analytical chemistry. The journal welcomes the submission of research papers which report studies concerning the development of new and significant analytical methodologies. In determining the suitability of submitted articles for publication, particular scrutiny will be placed on the degree of novelty and impact of the research and the extent to which it adds to the existing body of knowledge in analytical chemistry.