Development of theranostic nanoplatforms based on gadolinium-layered double hydroxides for magnetic resonance imaging-guided stimuli-enhanced chemotherapy
Leila Khalili , Gholamreza Dehghan , Hamed Hamishehkar , Leonid G. Voskressensky , Alireza Khataee
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引用次数: 0
Abstract
The requirements for non-invasive visualization and precise treatment of cancers are ongoing, demanding continuous efforts to enhance the development of potent theranostic modalities. Notably, groundbreaking advancements in nanotechnology have positioned layered double hydroxides (LDHs) at the forefront of biomedical research. LDH carriers are highly valued in medicinal applications due to their ability to integrate the benefits of multiple modalities, thus paving a promising path to clinical use. Recent breakthroughs in the rational design of theranostics have underscored the potential of gadolinium (Gd)-doped LDHs, which are particularly well-suited for the diagnosis of diseases. This review focuses on providing a comprehensive overview of the latest significant advances in Gd-LDH assemblies in cancer theranostics, with an emphasis on a bottom-up intercalation strategy, influential factors, and formulation methodologies. These aspects are crucial for researchers developing innovative intercalation processes and novel multi-component materials. Additionally, we address the kinetic inertness and colloidal stability of Gd-intercalated LDHs, which are essential for advanced theranostic applications. Finally, we present a forward-looking discussion on the challenges and future opportunities related to Gd-LDH complexes, aiming to identify the obstacles researchers encounter in advancing the clinical application of Gd-LDHs and to offer potential insights for further research.
期刊介绍:
Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers.
The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.