Trends and disability-attributable risk factors of type 2 diabetes mellitus in Southeast Asia (1990–2019): An in-depth 30-year analysis from the Global Burden of Disease study

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-09-30 DOI:10.1016/j.numecd.2024.09.020

Annisa Salsabilla Dwi Nugrahani , Farizal Rizky Muharram , Hermina Novida , Julian Benedict Swannjo , Sony Wibisono , Citrawati Dyah Kencono Wungu

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Abstract

Background and aims

To provide insight on targeted approach to mitigate diabetes burden, this research aims to analyze the trends of prevalence, mortality, and disability attributable to risk factors for type 2 diabetes mellitus (T2DM) from 1990 to 2019 in the Southeast Asia (SEA) region.

Methods and results

Age-standardized rates for prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (DALYs) from 1990 to 2019 from the Global Burden of Disease Study were assessed. DALYs-related risk factors were estimated using multivariate regression analysis and estimated annual percentage change (EAPC) was calculated to quantify the temporal trends. Over 30 years, the SEA region experienced a 59.5 % rise in T2DM ASPR, 17.33 % in ASMR, and 26.97 % in DALYs. The T2DM DALYs rate per 100,000 population was 1002.91 (885.23–1132.40) in 1990 and 1273.42 (1103.92–1452.41) in 2019, increasing by 27 %. Cambodia and Indonesia had the highest worsening in three parameters, while most significant improvement in all parameters was observed in Singapore. The curvilinear association was demonstrated between ASMR and DALYs to Gross Domestic Product (GDP) per capita. Prominent risk factors affecting DALYs increase were high fasting plasma glucose (FPG) (p < 0.001), high body mass index (BMI) (p < 0.001), tobacco use (p = 0.012), and household pollution (p = 0.03). Men were more affected than women.

Conclusion

The burden of T2DM in the SEA region has increased significantly during the 30-year period. Policymakers should address high BMI, high FPG, smoking, and air pollution to regulate T2DM burden in SEA.

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东南亚 2 型糖尿病的趋势和致残风险因素（1990-2019 年）：全球疾病负担研究的 30 年深入分析。

背景和目的：为深入了解减轻糖尿病负担的针对性方法，本研究旨在分析东南亚（SEA）地区1990年至2019年2型糖尿病（T2DM）风险因素导致的患病率、死亡率和残疾率的变化趋势：评估了全球疾病负担研究（Global Burden of Disease Study）中1990年至2019年的患病率（ASPR）、死亡率（ASMR）和残疾调整生命年（DALYs）的年龄标准化比率。使用多元回归分析估算了与残疾调整生命年相关的风险因素，并计算了估计年度百分比变化（EAPC），以量化时间趋势。30 年间，东南亚地区的 T2DM ASPR 上升了 59.5%，ASMR 上升了 17.33%，DALYs 上升了 26.97%。1990 年，每 10 万人中 T2DM DALYs 的比率为 1002.91（885.23-1132.40），2019 年为 1273.42（1103.92-1452.41），增加了 27%。柬埔寨和印度尼西亚的三个参数恶化幅度最大，而新加坡所有参数的改善幅度最大。ASMR与人均国内生产总值（GDP）的DALYs之间呈曲线关系。影响残疾调整寿命年数增加的主要风险因素是空腹血浆葡萄糖（FPG）过高（p）：东南亚地区的 T2DM 负担在 30 年间显著增加。决策者应解决高体重指数、高空腹血浆葡萄糖、吸烟和空气污染等问题，以控制东南亚地区的 T2DM 负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Metabolism and Cardiovascular Diseases 医学-内分泌学与代谢

CiteScore

6.80

自引率

2.60%

发文量

332

审稿时长

57 days

期刊介绍： Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.