Association of insulin resistance surrogate indices and erectile dysfunction: a systematic review and meta-analysis.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Reproductive Biology and Endocrinology Pub Date : 2024-11-19 DOI:10.1186/s12958-024-01317-4

Sayeh Jalali, Negar Zareshahi, Amir Hossein Behnoush, Alireza Azarboo, Amirhossein Shirinezhad, Seyyed Yasin Hosseini, Amin Javidan, Amirhossein Ghaseminejad-Raeini

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引用次数: 0

Abstract

Background: Erectile dysfunction (ED) has been linked to insulin resistance (IR), with various surrogate indices being used to assess this association. This systematic review and meta-analysis aimed to evaluate the relationship between IR indices and the incidence and severity of ED.

Methods: A comprehensive search across PubMed, Embase, Web of Science, and Scopus was carried out. Required data were extracted and meta-analyzed. The Newcastle-Ottawa Scale (NOS) was employed to evaluate the studies' risk of bias. Sensitivity analyses and meta-regressions were conducted to explore heterogeneity and the impact of confounding variables.

Results: Seventeen studies with a total of 3810 patients with ED and 8252 without ED were included. Meta-analysis revealed that males with ED had significantly higher levels of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) (SMD = 0.59, 95% CI [0.15, 1.03], I² = 82%, P < 0.01), Triglyceride-Glucose Index (TyG) (SMD = 0.53, 95% CI [0.31, 0.75], I² = 69%, P < 0.01), and Visceral Adiposity Index (VAI) (SMD = 0.45, 95% CI [0.25, 0.64], I² = 76%, P < 0.01) compared to those without ED. However, there was no significant correlation between a one-unit increase in HOMA-IR (OR = 0.63, 95% CI [0.03, 13.69], I² = 91%, P = 0.77) or TyG (OR = 0.53, 95% CI [0.02, 11.53], I² = 88%, P = 0.68) and the odds of ED. Additionally, a one-unit increase in VAI was associated with more severe ED (SMD = 0.34, 95% CI [0.03, 0.64], I² = 16%, P = 0.03). The diagnostic accuracy of these indices varied.

Conclusions: The results indicate a significant connection between insulin resistance and erectile dysfunction, as shown by HOMA-IR, TyG, and VAI. Yet, their usefulness in predicting ED is restricted because of significant differences and inconsistencies in diagnostic precision. More research is required to determine the clinical importance of these indices in treating ED.

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胰岛素抵抗代用指标与勃起功能障碍的关系：系统综述和荟萃分析。

背景：勃起功能障碍（ED）与胰岛素抵抗（IR）有关，有多种替代指标被用于评估这种关联。本系统综述和荟萃分析旨在评估胰岛素抵抗指数与勃起功能障碍的发生率和严重程度之间的关系：方法：对 PubMed、Embase、Web of Science 和 Scopus 进行了全面检索。提取所需数据并进行荟萃分析。采用纽卡斯尔-渥太华量表（NOS）评估研究的偏倚风险。进行了敏感性分析和元回归，以探讨异质性和混杂变量的影响：结果：共纳入了 17 项研究，涉及 3810 名 ED 患者和 8252 名非 ED 患者。元分析表明，男性 ED 患者的胰岛素抵抗稳态模型评估（HOMA-IR）水平（SMD = 0.59，95% CI [0.15，1.03]，I2 = 82%，P 2 = 69%，P 2 = 76%，P 2 = 91%，P = 0.77）或 TyG 水平（OR = 0.53，95% CI [0.02，11.53]，I2 = 88%，P = 0.68）明显高于 ED 的几率。此外，VAI 增加一个单位与更严重的 ED 相关（SMD = 0.34，95% CI [0.03，0.64]，I2 = 16%，P = 0.03）。这些指数的诊断准确性各不相同：结论：研究结果表明，HOMA-IR、TyG 和 VAI 显示胰岛素抵抗与勃起功能障碍之间存在重要联系。结论：结果表明，HOMA-IR、TyG 和 VAI 显示胰岛素抵抗与勃起功能障碍之间存在显著联系，但由于诊断精确度存在显著差异和不一致，它们在预测 ED 方面的作用受到限制。要确定这些指数在治疗 ED 方面的临床重要性，还需要进行更多的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Biology and Endocrinology 医学-内分泌学与代谢

CiteScore

7.90

自引率

2.30%

发文量

161

审稿时长

4-8 weeks

期刊介绍： Reproductive Biology and Endocrinology publishes and disseminates high-quality results from excellent research in the reproductive sciences. The journal publishes on topics covering gametogenesis, fertilization, early embryonic development, embryo-uterus interaction, reproductive development, pregnancy, uterine biology, endocrinology of reproduction, control of reproduction, reproductive immunology, neuroendocrinology, and veterinary and human reproductive medicine, including all vertebrate species.