Characterising the Time Course of the Dilatory Response of Healthy Retinal Arteries during Flicker-Light Provocation.

IF 1.8 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of Vascular Research Pub Date : 2024-11-19 DOI:10.1159/000541443

Robert J Summers, Rebekka Heitmar

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引用次数: 0

Abstract

Introduction: The dilatory response of healthy retinal arterioles to flicker-light (FL) provocation appears to be biphasic. The vessel diameter rapidly increases (acute phase) over 5-10 s, then barely increases thereafter (maintenance phase) until FL cessation. This reaction is usually characterised at a single point by two parameters: maximum dilation (MD) relative to baseline diameter (MD, %) and time to MD (RT, s). This paper describes the biphasic reaction of retinal arteries during FL provocation using a bi-linear function.

Methods: Retinal arterioles from 45 adults were examined during flicker provocation. Each individual time course of arterial diameter change during FL provocation was characterised by a bi-linear equation and compared with MD and RT.

Results: Slopes of the acute phase were 0.506%/s, and the maintenance phase was nearly flat (0.012%/s). The mean time at which the reaction changed from acute to maintenance phase was 7.4 s which is significantly different from RT (16.0 s). Mean dilation at this point (2.987%) was significantly different from MD (3.734%), but it was still 80% of MD in less than half of RT.

Conclusion: Bi-linear fitting parameters better characterises the arterial dilatory response than MD and RT. Further stratification of clinical groups using bi-linear fitting may provide insight of the underlying physiology of vessel dilation for different pathologies.

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描述闪烁光刺激时健康视网膜动脉扩张反应的时间过程

简介健康视网膜动脉对闪烁光（FL）刺激的扩张反应似乎是双相的。血管直径在 5-10 秒内迅速增大（急性期），之后几乎不再增大（维持期），直到 FL 停止。这种反应通常由两个参数来描述：相对于基线直径的最大扩张（MD）（MD，%）和达到 MD 的时间（RT，秒）。本文使用双线性函数描述了 FL 激发过程中视网膜动脉的双相反应：方法：对 45 名成人的视网膜动脉在闪烁激发时进行了检查。方法：在闪烁诱发过程中对 45 名成人的视网膜动脉血管进行检查，用双线性方程描述闪烁诱发过程中动脉直径变化的每个时间过程，并与 MD 和 RT 进行比较：结果：急性期的斜率为 0.506%/s，维持期几乎持平（0.012%/s）。反应从急性期转入维持期的平均时间为 7.4 秒，与 RT（16.0 秒）有显著差异。此时的平均扩张率（2.987%）与 MD（3.734%）有显著差异，但仍是 MD 的 80%，不到 RT 的一半：结论：与 MD 和 RT 相比，双线性拟合参数能更好地描述动脉扩张反应。结论：与 MD 和 RT 相比，双线性拟合参数能更好地描述动脉扩张反应，使用双线性拟合参数对临床群体进行进一步分层，可深入了解不同病理情况下血管扩张的潜在生理机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Vascular Research 医学-生理学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The ''Journal of Vascular Research'' publishes original articles and reviews of scientific excellence in vascular and microvascular biology, physiology and pathophysiology. The scope of the journal covers a broad spectrum of vascular and lymphatic research, including vascular structure, vascular function, haemodynamics, mechanics, cell signalling, intercellular communication, growth and differentiation. JVR''s ''Vascular Update'' series regularly presents state-of-the-art reviews on hot topics in vascular biology. Manuscript processing times are, consistent with stringent review, kept as short as possible due to electronic submission. All articles are published online first, ensuring rapid publication. The ''Journal of Vascular Research'' is the official journal of the European Society for Microcirculation. A biennial prize is awarded to the authors of the best paper published in the journal over the previous two years, thus encouraging young scientists working in the exciting field of vascular biology to publish their findings.