From live birth to live birth: a strong correlation between the outcomes of first and second frozen-thawed euploid blastocyst transfers from sibling oocytes.
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Abstract
Purpose: To investigate any correlation between the outcomes of the first euploid frozen-thawed blastocyst embryo transfer (FBT) and the subsequent euploid FBT derived from sibling oocytes.
Methods: This retrospective study analyzed data from 1051 women who underwent preimplantation genetic testing for aneuploidy and had a euploid FBT. Of these patients, 159 underwent a second transfer. The primary outcome was the live birth rate.
Results: Overall, 159 women who underwent a second euploid FBT were categorized into two subgroups depending on the implantation success of the first FBT. Of these patients, 94 (59.1%) belonged to the nonclinical group, signifying a negative result or a biochemical pregnancy. The remaining 65 (40.9%) patients belonged to the clinical group, indicating either a miscarriage or a live birth. In the binary logistic regression analysis, the live birth outcome during the first euploid FBT was a statistically significant and independent predictor of live birth in the subsequent FBT [odds ratio 4.14, 95% confidence interval (1.184-14.531), p < 0.026). Miscarriages, including those that occurred before intracytoplasmic sperm injection and in the first euploid FBT, reduced the live birth rate by approximately 34% (p < 0.027). No significant difference in the miscarriage rate was found between the two subgroups (19.2% (10/52) vs. 25.4% (14/55), p = 0.38).
Conclusion: The live birth outcome of the second euploid FBT is mainly determined by the live birth outcome of the first. Miscarriages that occurred before in vitro fertilization negatively affect the live birth outcome.
期刊介绍：
The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species.
The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.
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