Association of serum klotho with cognitive function among individuals with nonalcoholic fatty liver disease.

IF 4.1 2区医学 Q2 GERIATRICS & GERONTOLOGY

Frontiers in Aging Neuroscience Pub Date : 2024-11-05 eCollection Date: 2024-01-01 DOI:10.3389/fnagi.2024.1487182

Feilong Wu, Jie Pan, Mingtao Chen, Xuye Lai, Yingying Gu, Lei Pei, Lili Yang

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引用次数: 0

Abstract

Introduction: This study investigated the potential link between serum klotho levels and cognitive function in patients with non-alcoholic fatty liver disease (NAFLD).

Materials and methods: Utilizing NHANES data from 2011 to 2014, the research included 356 eligible participants. NAFLD was identified with the United States Fatty Liver Index (US-FLI), and cognition was measured by various tests including the Animal Fluency Test (AFT), Digit Symbol Substitution Test (DSST), Immediate Recall Test (IRT), and Delayed Recall Test (DRT). Weighted logistic regression and restricted cubic splines were employed to analyze the relationship between klotho levels and cognitive scores.

Results: A significant nonlinear association was observed between klotho levels and the performance in DSST and Delayed Recall Test (DRT). After controlling for confounding factors, the study found a positive association between higher serum klotho levels and improved cognitive performance in both AFT and DSST. However, there was no significant relationship between klotho levels and the IRT or DRT, regardless of whether the natural logarithm or quartile was considered.

Discussion: The findings suggest that a higher serum klotho level may be positively correlated with better cognitive performance in NAFLD patients.

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非酒精性脂肪肝患者血清 klotho 与认知功能的关系。

简介本研究调查了非酒精性脂肪肝（NAFLD）患者血清Klotho水平与认知功能之间的潜在联系：研究利用 2011 年至 2014 年的 NHANES 数据，纳入了 356 名符合条件的参与者。非酒精性脂肪肝通过美国脂肪肝指数（US-FLI）进行鉴定，认知能力通过各种测试进行测量，包括动物流畅性测试（AFT）、数字符号替换测试（DSST）、即时回忆测试（IRT）和延迟回忆测试（DRT）。采用加权逻辑回归和限制性三次样条来分析 klotho 水平与认知分数之间的关系：结果：klotho水平与DSST和延迟回忆测验（DRT）成绩之间存在明显的非线性关系。在控制了混杂因素后，研究发现血清 klotho 水平越高，AFT 和 DSST 的认知能力越好，两者之间呈正相关。然而，无论考虑自然对数还是四分位数，klotho水平与IRT或DRT之间均无明显关系：讨论：研究结果表明，较高的血清klotho水平可能与非酒精性脂肪肝患者较好的认知能力呈正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES

CiteScore

6.30

自引率

8.30%

发文量

1426

期刊介绍： Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.