Respiratory syncytial virus: Characteristics, complications and mortality in immunocompetent versus immunocompromised hospitalized adults in Northern Denmark

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2024-11-15 DOI:10.1016/j.diagmicrobio.2024.116605

Trine Langfeldt Hagen , Mette Juul Nitschke , Jesper Smit

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引用次数: 0

Abstract

Background

Respiratory syncytial virus (RSV) is an increasingly well-known cause of severe respiratory symptoms in adults. We aimed to describe characteristics, complications and in-hospital mortality of adults admitted to hospital with RSV-related respiratory symptoms.

Methods

Data were collected from electronic health records in the North Denmark Region for hospitalized adults diagnosed with RSV between April 1st - December 31st 2021. We collected data on characteristics, complications and mortality. Results were compared between immunocompromised and -competent patients.

Results

We included 111 patients. Sixty-five percent had comorbidities and 20 % received immunosuppressive drugs. Fifty-three percent had bacterial pneumonia and 61 % needed oxygen support. Mortality was 12 %. There were no differences in complications between the compared groups.

Conclusion

Severe respiratory symptoms were frequent among RSV-patients. Bacterial co-infections were common in the study population and mortality was considerable, regardless of known immunosuppression, thus warranting thorough and early investigations in RSV-positive patients.

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呼吸道合胞病毒：丹麦北部免疫功能正常与免疫功能低下的住院成年人的特征、并发症和死亡率。

背景：呼吸道合胞病毒（RSV）日益成为导致成人出现严重呼吸道症状的原因。我们旨在描述因 RSV 相关呼吸道症状而入院的成人的特征、并发症和院内死亡率：我们从北丹麦地区的电子健康记录中收集了 2021 年 4 月 1 日至 12 月 31 日期间确诊为 RSV 的住院成人的数据。我们收集了有关特征、并发症和死亡率的数据。结果：我们纳入了 111 名患者：我们纳入了 111 名患者。65%的患者患有合并症，20%的患者服用了免疫抑制剂。53%的患者患有细菌性肺炎，61%的患者需要氧气支持。死亡率为12%。两组患者的并发症没有差异：结论：RSV 患者经常出现严重的呼吸道症状。结论：RSV 阳性患者经常出现严重的呼吸道症状，细菌合并感染在研究人群中很常见，无论已知的免疫抑制情况如何，死亡率都很高，因此需要对 RSV 阳性患者进行彻底和早期的检查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.