The effect of a poly-herbal plant extract on the adhesion of Streptococcus mutans to tooth enamel.

IF 3.3 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

BMC Complementary Medicine and Therapies Pub Date : 2024-11-19 DOI:10.1186/s12906-024-04707-8

Cynthia J Henley-Smith, Anna-Mari Kok, Francien S Botha, Chantelle Baker, Namrita Lall

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Abstract

Background: Dental caries, also known as tooth decay or cavity formation, is one of the world's most widespread dental conditions. It is a plaque-related infection caused mainly by Streptococcus mutans. People have relied on several plant species to treat oral infections; Heteropyxis natalensis, for example, has been used to treat toothache and gum infections.

Methods: In this study, the antimicrobial and anti-adherence properties of H. natalensis and Camellia sinensis, as well as tea tree and peppermint essential oils were investigated on tooth enamel.

Results: The bacterial load of S. mutans was reduced by approximately two orders of a magnitude after 48 h, with a lesser extent on the commensal bacteria, Lactobacillus paracasei. Scanning electron micrographs of enamel blocks showed a reduction in the attachment and chain formation of S. mutans and degraded cell morphology. Lastly, the combination and each component individually, showed low to no cellular toxicity when tested on human macrophages.

Conclusions: This is the first report of this polyherbal regarding its selectivity and potential prevention of dental caries.

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多草本植物提取物对变异链球菌粘附在牙釉质上的影响

背景：龋齿，又称蛀牙或蛀洞，是世界上最普遍的牙科疾病之一。它是一种与牙菌斑有关的感染，主要由变异链球菌引起。人们依靠几种植物物种来治疗口腔感染，例如 Heteropyxis natalensis 就被用来治疗牙痛和牙龈感染：方法：在这项研究中，我们调查了桔梗、山茶以及茶树和薄荷精油对牙釉质的抗菌和抗粘附特性：结果：48 小时后，变异牙齿螺杆菌的细菌量减少了约两个数量级，对共生细菌副卡氏乳杆菌的影响较小。珐琅质块的扫描电子显微照片显示，变异沙雷氏菌的附着和链形成减少，细胞形态退化。最后，在对人类巨噬细胞进行测试时，组合物和每种成分都显示出较低甚至没有细胞毒性：这是首次报道这种多草药的选择性和预防龋齿的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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