Evaluation of arterial stiffness and quality of life in the treatment of moderate to severe obstructive sleep apnea with Continuous Positive Airway Pressure or Mandibular Advancement Appliance: a cross-sectional study.
Jessica Giovana Teixeira de Andrade, Maria de Lourdes Rabelo Guimaraes, Olivia Mendonça Nunes, Gabrielle Santos Pontello Neves, Patrícia de Souza Pereira, Jose Felippe Pinho da Silva, Maria da Gloria Rodrigues-Machado, Bruno Almeida Rezende
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引用次数: 0
Abstract
Background: Obstructive sleep apnea (OSA) is highly associated with a significant reduction in the Quality of Life (QoL) and is associated with deleterious effects on the cardiovascular system. Arterial stiffness is characterized by morphofunctional changes in the arteries and its assessment can be obtained non-invasively mainly through the measurement of pulse wave velocity (PWV). Arterial stiffness has been proposed as a predictor of cardiovascular diseases.
Objective: To compare arterial stiffness as well as QoL in patients diagnosed with moderate to severe OSA treated with Continuous Positive Airway Pressure (CPAP) or Mandibular Advancement Appliance (MAA) therapies.
Methods: This is a cross-sectional study involving 105 participants diagnosed with moderate to severe OSA categorized into three independent groups: A Non-treated Control Group and CPAP and MAA treated Groups. QoL was assessed by the Quebec Sleep Questionnaire (QSQ) and arterial stiffness was assessed noninvasively by Mobil-O-Graph.
Results: The groups were homogeneous, except for the polysomnographic parameters Apnea and Hypopnea Index (AHI) (p = 0.036) and Minimum O2 saturation (p = 0.011) (evaluated to diagnose the OSA condition before treatment) and Body Mass Index (BMI) (p < 0.001). The MAA group presented higher scores in all QoL domains (p < 0.05), except Social Interactions in relation to the Control group. For the CPAP group, only Nocturnal Symptoms presented significantly higher scores compared to the control group (p = 0.39). For Arterial Stiffness, no statistical differences were observed among comparisons.
Conclusions: Our results show better QoL scores in patients with OSA treated by CPAP and mainly by MAA. Differently, arterial stiffness parameters did not differ between the groups treated with CPAP and MAA and the control group.
背景：阻塞性睡眠呼吸暂停（OSA）与生活质量（QoL）的显著下降密切相关，并对心血管系统产生有害影响。动脉僵化以动脉的形态功能变化为特征，其评估可主要通过测量脉搏波速度（PWV）进行无创测量。动脉僵化被认为是心血管疾病的预测指标：比较接受持续气道正压（CPAP）或下颌前突矫正器（MAA）治疗的中重度 OSA 患者的动脉僵化程度和 QoL：这是一项横断面研究，涉及 105 名被诊断为中度至重度 OSA 的参与者，他们被分为三个独立的小组：非治疗对照组、CPAP 和 MAA 治疗组。QoL通过魁北克睡眠问卷（QSQ）进行评估，动脉僵化通过Mobil-O-Graph进行无创评估：除了多导睡眠图参数呼吸暂停和低通气指数（AHI）（P = 0.036）和最低血氧饱和度（P = 0.011）（治疗前诊断 OSA 的评估指标）以及体重指数（BMI）（P 结论：我们的研究结果表明，接受魁北克睡眠问卷（QSQ）评估的患者 QoL 评分更高，而接受 Mobil-O-Graph 评估的患者动脉僵化程度更高：我们的研究结果表明，使用 CPAP（主要是 MAA）治疗的 OSA 患者的 QoL 评分更高。不同的是，CPAP 和 MAA 治疗组与对照组之间的动脉僵化参数没有差异。
期刊介绍：
BMC Cardiovascular Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the heart and circulatory system, as well as related molecular and cell biology, genetics, pathophysiology, epidemiology, and controlled trials.
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