Innovative Psychedelic Therapies: Harnessing 5-MeO-DMT and DMT for Mental Health Treatment.

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2024-10-15 eCollection Date: 2024-11-14 DOI:10.1021/acsmedchemlett.4c00490

Robert B Kargbo

引用次数: 0

Abstract

Recent advancements in the therapeutic use of psychedelic compounds, particularly 5-MeO-DMT and DMT, have demonstrated significant potential in treating various mental health disorders. This Patent Highlight evaluates findings from multiple recent patents that explore novel applications of these compounds, including their use in severe psychiatric conditions such as depression, anxiety, and trauma-related disorders. The patents reveal innovative strategies, such as combining 5-MeO-DMT with mood preparation agents to enhance safety and efficacy, developing DMT prodrugs for improved pharmacokinetics, and targeting specific populations like breastfeeding mothers with tailored psychedelic therapies. These advancements offer new hope for patients with treatment-resistant mental disorders, highlighting the evolving role of psychedelics in mental health care.

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创新迷幻疗法：利用 5-MeO-DMT 和 DMT 治疗精神疾病。

迷幻化合物，尤其是 5-MeO-DMT 和 DMT 在治疗方面的最新进展表明，它们在治疗各种精神疾病方面具有巨大潜力。本专利集锦评估了近期多项专利的研究成果，这些专利探索了这些化合物的新型应用，包括它们在抑郁症、焦虑症和创伤相关疾病等严重精神疾病中的应用。这些专利揭示了创新策略，例如将 5-MeO-DMT 与情绪准备剂结合使用以提高安全性和疗效，开发 DMT 原药以改善药代动力学，以及针对特定人群（如哺乳期母亲）提供量身定制的迷幻疗法。这些进展为耐药性精神障碍患者带来了新的希望，凸显了迷幻药在精神保健中不断发展的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.