Peptide-functionalized magnetic microcapsules loaded with dexamethasone for dual active targeted treatment of inner ear inflammation

IF 4.1 2区化学 Q2 POLYMER SCIENCE

Polymer Pub Date : 2024-11-19 DOI:10.1016/j.polymer.2024.127864

Delia Mihaela Rata , Anca Niculina Cadinoiu , Leonard Ionut Atanase , Gabriela Vochita , Sverre Arne Sande , Marcel Popa

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Abstract

Conventional administration of drugs to the inner ear involves therapeutic instability and non-specificity of release, and to overcome these limitations, various drug delivery systems have been developed. The aim of this study was to prepare and characterize peptides-functionalized oligochitosan microcapsules loaded with Dexamethasone and magnetic nanoparticles, which can be used for dual active targeted treatment of inner ear inflammation. The diameter of spherical microcapsules in aqueous solutions was found in the micrometer range. In vitro dexamethasone release kinetics, capsules biodegradation, haemolysis and cellular viability on V79-4 normal cells were also investigated. The release efficiency of dexamethasone from the microcapsules was between 74 % and 99.8 % after 24 h. Obtained results indicated that all analyzed microcapsules showed hemolysis degrees lower than 3 %, which demonstrated their non-hemolytic character. The viability and morphology tests on V79-4 cells depended on the administered dose and after a 48-h treatment, all analyzed capsules showed a non-toxic, weak or moderately cytotoxic effect.

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装载地塞米松的多肽功能化磁性微胶囊用于内耳炎症的双重活性靶向治疗

传统的内耳给药存在治疗不稳定性和释放的非特异性，为了克服这些局限性，人们开发了各种给药系统。本研究旨在制备和表征载入地塞米松和磁性纳米颗粒的肽功能化低聚壳聚糖微胶囊，该微胶囊可用于内耳炎症的双重活性靶向治疗。在水溶液中，球形微胶囊的直径在微米范围内。此外，还研究了地塞米松的体外释放动力学、胶囊的生物降解、溶血以及 V79-4 正常细胞的细胞活力。24 小时后，地塞米松从微胶囊中的释放效率在 74% 到 99.8% 之间。结果表明，所有被分析的微胶囊的溶血度均低于 3%，这表明它们不溶血。对 V79-4 细胞进行的存活率和形态测试取决于给药剂量，经过 48 小时的处理后，所有分析的胶囊都显示出无毒、微弱或中等程度的细胞毒性作用。

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来源期刊

Polymer 化学-高分子科学

CiteScore

7.90

自引率

8.70%

发文量

959

审稿时长

32 days

期刊介绍： Polymer is an interdisciplinary journal dedicated to publishing innovative and significant advances in Polymer Physics, Chemistry and Technology. We welcome submissions on polymer hybrids, nanocomposites, characterisation and self-assembly. Polymer also publishes work on the technological application of polymers in energy and optoelectronics. The main scope is covered but not limited to the following core areas: Polymer Materials Nanocomposites and hybrid nanomaterials Polymer blends, films, fibres, networks and porous materials Physical Characterization Characterisation, modelling and simulation* of molecular and materials properties in bulk, solution, and thin films Polymer Engineering Advanced multiscale processing methods Polymer Synthesis, Modification and Self-assembly Including designer polymer architectures, mechanisms and kinetics, and supramolecular polymerization Technological Applications Polymers for energy generation and storage Polymer membranes for separation technology Polymers for opto- and microelectronics.