Rhodium(III)-Catalyzed Regioselective C4 Alkylation of Indoles with Nitroalkenes

Abstract

The Rh(III)-catalyzed indole C4–H bond addition to nitroalkenes is disclosed under mild and redox-neutral reaction conditions, offering straightforward access to various 4-(2-nitroalkyl)indoles (34 examples) with excellent chemo- and regioselectivity. Furthermore, late-stage diversifications and mechanistic studies were also performed.