Epigenetic scars of Brca1 loss point toward breast cancer cell of origin

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2024-11-20 DOI:10.1038/s41588-024-02021-0

Steven M. Lewis, Camila dos Santos

引用次数: 0

Abstract

The two-hit hypothesis suggests that a second mutation is necessary for cancer development in cells with a defective tumor-suppressor gene, such as BRCA1. However, a study now shows that the loss of just one Brca1 allele in mice can pre-program cells for cancer-promoting changes, indicating cancer may progress earlier than previously thought.

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Brca1缺失的表观遗传学疤痕指向乳腺癌起源细胞

两击假说认为，在肿瘤抑制基因（如 BRCA1）有缺陷的细胞中，癌症的发生需要第二次突变。然而，现在的一项研究表明，小鼠只要失去一个BRCA1等位基因，细胞就会发生促癌变化的预编程，这表明癌症的发展可能比以前想象的要早。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution