Advancing COVID-19 Diagnosis: Enhancement in SERS-PCR with 30-nm Au Nanoparticle-Internalized Nanodimpled Substrates (Small 46/2024)

IF 13 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Small Pub Date : 2024-11-19 DOI:10.1002/smll.202470336

Hajun Dang, Younju Joung, Jun-Yeong Yang, Soo Hyun Lee, Seunghun Lee, Sang-Woo Joo, Sung-Gyu Park, Jaebum Choo

引用次数: 0

Abstract

Molecular Diagnostic Systems

Using an Au nanoparticles-Au nanodimples (AuNPs-AuNDPs) substrate, in article number 2403672, Sang-Woo Joo, Sung-Gyu Park, Jaebum Choo, and co-workers developed a highly sensitive surface-enhanced Raman scattering (SERS)-polymerase chain reaction molecular diagnostic assay platform capable of detecting 10⁵ copies/μL of the SARS-CoV-2 target gene with a minimal number of thermocycles. These results are expected to ultimately lay the foundation for developing SERS-based amplification-free molecular diagnostic systems.

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推进 COVID-19 诊断：利用 30 纳米金纳米粒子内化纳米点阵基底增强 SERS-PCR (Small 46/2024)

分子诊断系统利用金纳米颗粒-金纳米微粒（AuNPs-AuNDPs）基底，Sang-Woo Joo、Sung-Gyu Park、Jaebum Choo 及其合作者在文章编号 2403672 中开发了一种高灵敏度的表面增强拉曼散射（SERS）-聚合酶链反应分子诊断测定平台，该平台能够以最少的热循环次数检测出 105 个拷贝/μL 的 SARS-CoV-2 目标基因。这些结果有望最终为开发基于 SERS 的无扩增分子诊断系统奠定基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Small 工程技术-材料科学：综合

CiteScore

17.70

自引率

3.80%

发文量

1830

审稿时长

2.1 months

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