Endocytic tagging for degradation

IF 26.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Nature Biomedical Engineering Pub Date : 2024-11-19 DOI:10.1038/s41551-024-01293-5

Filipe V. Almeida

引用次数: 0

Abstract

Proteins that tag surface receptors for degradation by triggering their endocytosis can be computationally designed so that they do not compete with native receptor ligands for binding.

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内切酶标记降解

通过触发受体的内吞作用来标记表面受体以便降解的蛋白质可以通过计算设计出来，使其不会与原生受体配体竞争结合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Biomedical Engineering Medicine-Medicine (miscellaneous)

CiteScore

45.30

自引率

1.10%

发文量

138

期刊介绍： Nature Biomedical Engineering is an online-only monthly journal that was launched in January 2017. It aims to publish original research, reviews, and commentary focusing on applied biomedicine and health technology. The journal targets a diverse audience, including life scientists who are involved in developing experimental or computational systems and methods to enhance our understanding of human physiology. It also covers biomedical researchers and engineers who are engaged in designing or optimizing therapies, assays, devices, or procedures for diagnosing or treating diseases. Additionally, clinicians, who make use of research outputs to evaluate patient health or administer therapy in various clinical settings and healthcare contexts, are also part of the target audience.