Evaluation of point-of-care capillary and venous blood glucose concentrations in hospitalized neonatal foals

IF 1.1 3区农林科学 Q3 VETERINARY SCIENCES

Journal of veterinary emergency and critical care Pub Date : 2024-11-18 DOI:10.1111/vec.13429

Ana Sofia Dias Moreira DVM, DACVIM, DACVECC, Hsin-Yi Weng BVM, MPH, PhD, Laura D. Hostnik DVM, MS, DACVIM, Erin M. Beasley DVM, PhD, DACVIM, Simon F. Peek BVSc, PhD, DACVIM, Amelia S. Munsterman DVM, PhD, DACVS, DACVECC

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引用次数: 0

Abstract

Objective

To compare glucose measurements from capillary and venous blood samples using a point-of-care (POC) glucometer with a standard laboratory (colorimetric, glucose oxidase) assay (LABGLU) in a population of hospitalized, neonatal foals.

Design

Multicenter, prospective, experimental study, conducted between March 2019 and June 2020.

Setting

Four university teaching hospitals and 1 private referral hospital.

Animals

Fifty-four hospitalized neonatal (≤30 days of age) foals.

Interventions

Simultaneous capillary (muzzle, POCMUZ) and venous (jugular, POCJUG) blood samples were obtained to determine POC glucose concentrations. Venous samples were also analyzed by LABGLU. Each foal was sampled at the time of enrollment or admission to the hospital and at 1 subsequent point during hospitalization. Indirect mean arterial pressure and hematocrit were concurrently recorded.

Measurements and Main Results

Bland–Altman analysis showed a mean bias (95% limits of agreement) of −28.0 (−88.6 to 32.6) mg/dL for comparison of POCJUG with LABGLU, −8.2 (−94.3 to 78.0) mg/dL for POCMUZ and LABGLU, and 18.8 (−44.4 to 82.0) mg/dL for POCMUZ and POCJUG. A total of 63.5% of the POCJUG and 45.2% of the POCMUZ samples exceeded the reference value by ±15 mg/dL (for LABGLU samples <75 mg/dL) or ±15% (for LABGLU samples ≥75mg/dL). Concordance correlation coefficient (95% confidence interval [CI]) indicated a fair agreement between POCJUG and LABGLU (0.75, 95% CI: 0.66–0.82) and between POCMUZ and LABGLU (0.71, 95% CI: 0.58–0.80). Fifty percent (14/28) of hypoglycemic foals on the reference method were incorrectly classified as euglycemic by POCJUG, and 5 of 28 were incorrectly classified by POCMUZ.

Conclusions

In the sampled population, the chosen POC glucometer lacked agreement with the standard laboratory measurement. Limits of agreement were wide for both POCJUG and POCMUZ. Inaccuracies in POC results could impact decision-making in the clinical management of glycemic control in hospitalized neonatal foals and, importantly, increase the risk of hypoglycemic events being underdiagnosed in critical patients.

Abstract Image

查看原文本刊更多论文

评估住院新生马驹的护理点毛细血管和静脉血糖浓度。

目的比较使用护理点（POC）血糖仪和标准实验室（比色法、葡萄糖氧化酶）测定法（LABGLU）对住院新生马驹的毛细血管和静脉血液样本进行的葡萄糖测量：多中心、前瞻性、实验研究，2019 年 3 月至 2020 年 6 月期间进行：四所大学教学医院和一所私立转诊医院：54只住院新生马驹（≤30日龄）：同时采集毛细血管（口腔，POCMUZ）和静脉（颈静脉，POCJUG）血样，以确定 POC 葡萄糖浓度。静脉血样本也通过 LABGLU 进行分析。每匹马驹都在报名或入院时以及住院期间的一个时间点采集血样。同时记录间接平均动脉压和血细胞比容：Bland-Altman分析显示，POCJUG与LABGLU的平均偏差（95%的一致性）为-28.0（-88.6至32.6）mg/dL，POCMUZ与LABGLU的平均偏差为-8.2（-94.3至78.0）mg/dL，POCMUZ与POCJUG的平均偏差为18.8（-44.4至82.0）mg/dL。63.5% 的 POCJUG 和 45.2% 的 POCMUZ 样品超出参考值 ±15 mg/dL（LABGLU 样品的结论）：在抽样人群中，所选的 POC 血糖仪与标准实验室测量值不一致。POCJUG 和 POCMUZ 的一致性限值较宽。POC 结果的不准确性可能会影响住院新生马驹血糖控制的临床管理决策，更重要的是，会增加危重患者低血糖事件被漏诊的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of veterinary emergency and critical care 农林科学-兽医学

CiteScore

2.50

自引率

15.40%

发文量

121

审稿时长

18-36 weeks

期刊介绍： The Journal of Veterinary Emergency and Critical Care’s primary aim is to advance the international clinical standard of care for emergency/critical care patients of all species. The journal’s content is relevant to specialist and non-specialist veterinarians practicing emergency/critical care medicine. The journal achieves it aims by publishing descriptions of unique presentation or management; retrospective and prospective evaluations of prognosis, novel diagnosis, or therapy; translational basic science studies with clinical relevance; in depth reviews of pertinent topics; topical news and letters; and regular themed issues. The journal is the official publication of the Veterinary Emergency and Critical Care Society, the American College of Veterinary Emergency and Critical Care, the European Veterinary Emergency and Critical Care Society, and the European College of Veterinary Emergency and Critical Care. It is a bimonthly publication with international impact and adheres to currently accepted ethical standards.