Comparison of intranasal atipamezole by atomization or drops with intramuscular injection for reversing sedative effects of medetomidine in healthy dogs

IF 1.1 3区 农林科学 Q3 VETERINARY SCIENCES
Majid Jafarbeglou DVM, DVSc, Mehdi Marjani DVM, DVSc, Mohammadreza Oghbaei DVM, Mohammadreza Paryani DVM, PhD, Reza Bakhshi-Khanghah DVM
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引用次数: 0

Abstract

Objective

To determine and compare the efficacy of intranasal (IN) atomization, IN drops, and IM injection of atipamezole for reversal of medetomidine-induced sedation in healthy dogs.

Design

Prospective, randomized, blinded study.

Setting

University teaching hospital.

Animals

Forty mixed-breed, shelter-owned dogs with an average weight of 29.9 ± 5.6 kg (mean ± SD) that required sedation for minor diagnostic or therapeutic procedures.

Interventions

Atipamezole was administered by a dog handler at 200 µg/kg via IN atomization (ATI-INA, n = 10), IN drops (ATI-IND, n = 10), or IM injection (ATI-IM, n = 10) 20 minutes following medetomidine administration (40 µg/kg). A control group (n = 10) received no atipamezole.

Measurements and Main Results

Ease of atipamezole administration was evaluated. Sedation score, heart rate (HR), respiratory rate (RR), and blood pressure (BP) were recorded pre-medetomidine administration (T0), pre-atipamezole administration (T20), and at multiple intervals following atipamezole administration. ATI-IM resulted in the fastest recovery, followed by ATI-INA, with ATI-IND being the slowest. The adverse cardiovascular impacts of medetomidine were not completely mitigated. ATI-IM showed initial HR restoration followed by a decline. HR in both IN groups showed a slower increase compared to ATI-IM, but no subsequent decline was observed. ATI-IM resulted in a transient decrease in BP, though dogs remained normotensive. A gradual reduction in BP was noted in the IN groups. At T50, RR of all atipamezole groups differed from control, and a significant increase in RR was observed in ATI-IM dogs compared to pre-atipamezole value. No adverse effects were observed.

Conclusions

All routes for atipamezole administration effectively reversed medetomidine-induced sedation, with ATI-IM being fastest. IN routes were easy for the dog handler to administer, making them viable alternatives in cases of accidental drug exposure, particularly outside a hospital setting.

比较雾化或滴鼻阿替帕米唑与肌肉注射阿替帕米唑对健康狗逆转美托咪定镇静作用的效果。
目的确定并比较阿替帕米唑鼻内雾化、鼻内滴注和IM注射对逆转美托咪定诱导的健康犬镇静的疗效:前瞻性、随机、盲法研究:动物40只由收容所饲养的混种犬,平均体重为29.9±5.6千克(平均值±标清值),这些犬在进行小型诊断或治疗过程时需要镇静剂:在注射美托咪定(40 微克/千克)20 分钟后,由驯犬师通过 IN 雾化法(ATI-INA,n = 10)、IN 滴注法(ATI-IND,n = 10)或 IM 注射法(ATI-IM,n = 10)注射阿替帕米唑,剂量为 200 微克/千克。对照组(n = 10)不使用阿替帕米唑:评估阿替帕美唑给药的难易程度。在使用美托咪啶前(T0)、使用阿替帕唑前(T20)和使用阿替帕唑后的多个时间间隔记录镇静评分、心率(HR)、呼吸频率(RR)和血压(BP)。ATI-IM恢复最快,其次是ATI-INA,ATI-IND恢复最慢。美托咪定对心血管的不良影响并未完全缓解。ATI-IM组的心率在恢复初期有所下降。与 ATI-IM 相比,IN 组的心率上升较慢,但没有观察到随后的下降。ATI-IM 导致血压短暂下降,但狗的血压仍然正常。IN 组的血压逐渐下降。T50时,所有阿替帕唑组的RR均与对照组不同,与阿替帕唑前的值相比,ATI-IM组的RR显著增加。未观察到不良反应:所有阿替帕米唑给药途径都能有效逆转美托咪定诱导的镇静,其中 ATI-IM 最快。IN给药途径对于训犬员来说很容易操作,因此在意外接触药物的情况下是可行的替代方法,尤其是在医院以外的环境中。
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来源期刊
CiteScore
2.50
自引率
15.40%
发文量
121
审稿时长
18-36 weeks
期刊介绍: The Journal of Veterinary Emergency and Critical Care’s primary aim is to advance the international clinical standard of care for emergency/critical care patients of all species. The journal’s content is relevant to specialist and non-specialist veterinarians practicing emergency/critical care medicine. The journal achieves it aims by publishing descriptions of unique presentation or management; retrospective and prospective evaluations of prognosis, novel diagnosis, or therapy; translational basic science studies with clinical relevance; in depth reviews of pertinent topics; topical news and letters; and regular themed issues. The journal is the official publication of the Veterinary Emergency and Critical Care Society, the American College of Veterinary Emergency and Critical Care, the European Veterinary Emergency and Critical Care Society, and the European College of Veterinary Emergency and Critical Care. It is a bimonthly publication with international impact and adheres to currently accepted ethical standards.
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