Evaluation of the safety and effect of lyophilized canine-specific albumin to increase serum albumin concentration and colloid osmotic pressure in healthy dogs

IF 1.1 3区农林科学 Q3 VETERINARY SCIENCES

Journal of veterinary emergency and critical care Pub Date : 2024-11-18 DOI:10.1111/vec.13432

Brittany D. Enders DVM, DACVECC, Sarah E. Musulin DVM, DACVECC, Marie K. Holowaychuk DVM, DACVECC, Anne S. Hale DVM

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引用次数: 0

Abstract

Objective

To evaluate the safety of repeated administration of a lyophilized canine-specific albumin (CSA) product and to quantify its effect on serum albumin concentrations and colloid osmotic pressure (COP) in healthy dogs.

Design

Prospective study.

Setting

University research facility.

Animals

Six healthy, adult, purpose-bred Beagles.

Interventions

Dogs received 1 g/kg of 16% CSA intravenously on days 1, 2, and 14 and were observed, with serial measurement of vital parameters during and for 2 hours after each infusion, to monitor for adverse events or evidence of a hypersensitivity reaction. Serum albumin concentration and COP were measured at predetermined time points before and after each infusion.

Results

One dog experienced a single episode of vomiting approximately 1 hour after completion of the second infusion. No other adverse reactions were observed during the 28-day study period. Serum albumin concentration was increased by a mean of 0.57 g/dL (5.7 g/L) (P = 0.003) when measured 2 hours after the first CSA infusion, and albumin concentration remained significantly higher than baseline at 24 hours after infusion, with a mean difference of 0.42 g/dL (4.2 g/dL) (P < 0.001). The second and third CSA infusions similarly increased serum albumin concentration at 2 hours (P = 0.001 and P = 0.001, respectively) and 24 hours (P = 0.012 and P = 0.007, respectively) after infusion. COP increased by a mean of 2.03 mm Hg at 2 hours after the first infusion (P = 0.013) and remained significantly higher than baseline at 24 hours after infusion, with a mean difference of 1.52 mm Hg (P = 0.002). The second CSA infusion similarly increased COP at 2 hours (P < 0.001) and 24 hours (P = 0.017) after infusion. The third CSA infusion increased COP at 2 hours after infusion (P = 0.004) but did not achieve statistical significance at 24 hours after infusion (P = 0.053).

Conclusions

A 1-g/kg dose of lyophilized CSA was effective at increasing serum albumin concentration and COP. Repeated infusions of CSA appear safe in healthy dogs.

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评估冻干犬特异性白蛋白提高健康犬血清白蛋白浓度和胶体渗透压的安全性和效果。

目的评估重复服用冻干犬特异性白蛋白（CSA）产品的安全性，并量化其对健康犬血清白蛋白浓度和胶体渗透压（COP）的影响：设计：前瞻性研究：设计：前瞻性研究：六只健康、成年、专门饲养的比格犬：第 1 天、第 2 天和第 14 天，给狗静脉注射 1 克/千克的 16% CSA，并在每次输液期间和输液后 2 小时内观察和连续测量生命参数，以监测不良事件或超敏反应的证据。在每次输注前后的预定时间点测量血清白蛋白浓度和 COP：结果：一只狗在完成第二次输注约 1 小时后出现一次呕吐。在 28 天的研究期间未观察到其他不良反应。在第一次输注 CSA 2 小时后测量血清白蛋白浓度，其平均值增加了 0.57 g/dL (5.7 g/L)（P = 0.003），输注 24 小时后白蛋白浓度仍显著高于基线值，平均值相差 0.42 g/dL (4.2 g/dL)（P 结论：在输注 CSA 2 小时后测量血清白蛋白浓度，其平均值增加了 0.57 g/dL (5.7 g/L)（P = 0.003），输注 24 小时后白蛋白浓度仍显著高于基线值：1克/千克剂量的冻干 CSA 能有效提高血清白蛋白浓度和 COP。对健康犬重复输注 CSA 似乎是安全的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of veterinary emergency and critical care 农林科学-兽医学

CiteScore

2.50

自引率

15.40%

发文量

121

审稿时长

18-36 weeks

期刊介绍： The Journal of Veterinary Emergency and Critical Care’s primary aim is to advance the international clinical standard of care for emergency/critical care patients of all species. The journal’s content is relevant to specialist and non-specialist veterinarians practicing emergency/critical care medicine. The journal achieves it aims by publishing descriptions of unique presentation or management; retrospective and prospective evaluations of prognosis, novel diagnosis, or therapy; translational basic science studies with clinical relevance; in depth reviews of pertinent topics; topical news and letters; and regular themed issues. The journal is the official publication of the Veterinary Emergency and Critical Care Society, the American College of Veterinary Emergency and Critical Care, the European Veterinary Emergency and Critical Care Society, and the European College of Veterinary Emergency and Critical Care. It is a bimonthly publication with international impact and adheres to currently accepted ethical standards.