Relationship between macular microvasculature and visual function in idiopathic macular epiretinal membrane by using OCT angiography and multifocal electroretinogram

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2024-11-17 DOI:10.1016/j.pdpdt.2024.104403

Haiyue Xu , Yu Wang , Bo Zou , Meilin Liu , Chunmeng Dai , Yuchen Zheng , Xiaoxia Ding

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引用次数: 0

Abstract

Purpose

To investigate the relationship between microvasculature and visual function in idiopathic epiretinal membrane (iERM).

Methods

This retrospective study included 30 iERM eyes. Macular microvasculature was evaluated by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). Visual function was evaluated by best corrected visual acuity (BCVA) and multifocal electroretinogram (mfERG). All parameters were measured in the iERM patients at baseline, 1 month, and 3 months postoperatively. Associations between macular microvasculature and visual function were evaluated.

Results

BCVA, central retinal thickness (CRT) and parafoveal vessel density (PFVD) of the deep capillary plexus (DCP) changed significantly 3 months after surgery. P1 amp density and amplitude of ring 1 decreased significantly 3 months postoperatively. P1 implicit time of ring 1 was shortened after surgery. Baseline PFVD of DCP was negatively correlated with the postoperative BCVA, and baseline BCVA was positively correlated with the postoperative BCVA. Baseline foveal avascular zone (FAZ) and P1 amplitude of ring 1 were positively correlated with the postoperative P1 amplitude of ring 1 (p < 0.05). Multiple linear regression analysis revealed that baseline PFVD of DCP was a predictor of the postoperative BCVA, and baseline FAZ was a predictor of the postoperative P1 amplitude of ring 1 (p < 0.05).

Conclusion

Although visual acuity and CRT improved after iERM surgery, visual function estimated by mfERG had a limited recovery 3 months postoperatively. Baseline PFVD of the DCP and FAZ were predictors of visual function after the iERM surgery.

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利用 OCT 血管造影和多焦视网膜电图研究特发性黄斑视网膜外膜的黄斑微血管与视觉功能之间的关系

目的：研究特发性视网膜外膜（iERM）微血管与视觉功能之间的关系：这项回顾性研究包括 30 只特发性视网膜外膜（iERM）眼。通过光学相干断层扫描（OCT）和光学相干断层血管成像（OCTA）对黄斑微血管进行评估。视觉功能通过最佳矫正视力（BCVA）和多焦视网膜电图（mfERG）进行评估。所有参数都是在 iERM 患者的基线、术后 1 个月和 3 个月时测量的。评估了黄斑微血管与视觉功能之间的关联：结果：BCVA、视网膜中央厚度（CRT）和深部毛细血管丛（DCP）的眼底血管密度（PFVD）在术后 3 个月发生了显著变化。术后 3 个月，1 号环的 P1 amp 密度和振幅明显下降。术后 1 号环的 P1 植入时间缩短。DCP 的基线 PFVD 与术后 BCVA 呈负相关，而基线 BCVA 与术后 BCVA 呈正相关。基线眼窝无血管区（FAZ）和 1 号环的 P1 波幅与术后 1 号环的 P1 波幅呈正相关（P < 0.05）。多元线性回归分析显示，DCP的基线PFVD是术后BCVA的预测因子，基线FAZ是术后1号环P1振幅的预测因子（P < 0.05）：结论：虽然 iERM 手术后视力和 CRT 有所改善，但术后 3 个月 mfERG 估算的视功能恢复有限。DCP和FAZ的基线PFVD是iERM手术后视功能的预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.