Failure mode and effects analysis-based strategies for controlling multidrug-resistant organism infections in cancer patients.

IF 3.8 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Scientific Reports Pub Date : 2024-11-19 DOI:10.1038/s41598-024-80282-9

Chunlin Wu, Qingqing Tian, Hui Wang, Weiwei Yang, Anran Liu, Jiayang Tang, Xiaoyan Nie, Ruiying Pu, Qin Huang

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引用次数: 0

Abstract

In the context of advancing medical procedures, postoperative infections in cancer patients, particularly those involving multidrug-resistant organisms, have become a significant clinical concern. This study aims to comprehensively and systematically evaluate the effectiveness of infection prevention and control for multidrug-resistant organisms (MDROs) in postoperative cancer patients using Failure Mode and Effects Analysis (FMEA). This study was conducted in a tertiary A-level cancer specialty hospital in China, employing Failure Mode and Effects Analysis (FMEA) to assess the risks of hospital infections. Intervention measures were implemented for high-risk and medium-high-risk factors. Through the hospital's infection information system, data on patients who underwent surgical treatment from 2017 to 2022 were extracted. Data from 2017 to 2019 served as the control group, and data from 2020 to 2022 as the intervention group, to compare the changes in hospital infection incidence and MDRO infection incidence before and after the intervention. Categorical data were described in terms of frequency and percentage. The chi-square test was utilized for statistical inference to assess the differences in infection rates before and after the intervention. Prior to the intervention (2017-2019), the incidence rate of hospital infections was 1.66%, which decreased to 1.22% after the intervention (2020-2022), showing a statistically significant difference (χ² = 48.83, P < 0.001). The incidence rate of MDRO infections also decreased from 1.808‰ before the intervention to 1.136‰ after the intervention, with a statistically significant difference (χ² = 11.417, P = 0.001). This study confirms the effectiveness of the FMEA method in preventing and controlling MDRO infections in postoperative cancer patients. It highlights the practicality and value of widespread adoption of this method, particularly in the context of the COVID-19 pandemic.

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基于失效模式和效应分析的癌症患者耐多药生物感染控制策略。

在医疗程序不断发展的背景下，癌症患者的术后感染，尤其是涉及耐多药生物的术后感染，已成为临床关注的一个重要问题。本研究旨在采用失效模式与效应分析法（FMEA），全面系统地评估癌症术后患者耐多药病原体（MDRO）感染防控的有效性。本研究在中国一家三级甲等肿瘤专科医院进行，采用失效模式与效应分析法（FMEA）评估医院感染风险。针对高风险和中高风险因素采取了干预措施。通过医院感染信息系统，提取了2017年至2022年接受手术治疗的患者数据。2017年至2019年的数据作为对照组，2020年至2022年的数据作为干预组，比较干预前后医院感染发生率和MDRO感染发生率的变化。分类数据用频率和百分比来描述。采用卡方检验进行统计推断，以评估干预前后感染率的差异。干预前（2017-2019 年），医院感染发生率为 1.66%，干预后（2020-2022 年）下降至 1.22%，差异有统计学意义（χ2 = 48.83，P 2 = 11.417，P = 0.001）。本研究证实了 FMEA 方法在预防和控制癌症术后患者 MDRO 感染方面的有效性。它强调了广泛采用这种方法的实用性和价值，尤其是在 COVID-19 大流行的背景下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

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