Single and joint exposure of Pb, Cd, Hg, Se, Cu, and Zn were associated with cognitive function of older adults.

IF 3.8 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Scientific Reports Pub Date : 2024-11-19 DOI:10.1038/s41598-024-79720-5

Zixuan Fu, Xiaofang Xu, Li Cao, Qianying Xiang, Qian Gao, Huirong Duan, Shuhan Wang, Liye Zhou, Xiujuan Yang

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引用次数: 0

Abstract

Background: Impaired cognitive function following exposure to heavy metals has emerged as a significant global health concern. Nevertheless, the impact of combined exposure to multiple heavy metals on cognitive impairment remains unclear.

Objective: This study aimed to explore the association between multiple heavy metals exposure and cognitive function to provide theoretical evidence to guide prevention strategies.

Methods: The blood levels of lead (Pb), cadmium (Cd), mercury (Hg), selenium (Se), copper (Cu) and zinc (Zn) and the results of the cognitive function tests were extracted from 811 elderly Americans who completed the NHANES between 2011 and 2014. Quantile regression (QR), restricted cubic splines (RCS), and Bayesian kernel machine regression (BKMR) were used to explore the individual and joint association between heavy metals exposure and performance in 4 standardized cognitive tests; Item Response Theory (IRT), Delayed Recall Test (DRT), Animal Fluency Test (AFT) and Digit Symbol Substitution Test (DSST).

Results: A negative association was noted between Cd levels and IRT (p = 0.048, 95%CI: -2.7, -0.1). Se concentrations ranging between 2.197 µg/L (95%CI: 0.004, 0.15) to 2.29 µg/L (95%CI: 2.56, 7.64) (log₁₀Se) was postively associated with DSST (p = 0.001 ). Cu was negatively associated with DSST (p = 0.049, 95%CI: -37.75, -0.09), while Zn was positively associated with IRT (p = 0.022, 95%CI: 0.55, 11.73). Exposure to the 6 heavy metals combined showed a positive linear association with IRT, DRT, and a negative linear association with DSST. An interaction between Cd and the other heavy metals (excepted for Pb).

Conclusion: Exposure to Pb, Cd, Hg, Se, Cu, and Zn was associated with cognitive function. Joint exposure to the 6 heavy metals showed a positive linear association with IRT, DRT, contrarily, a negative linear association with DSST.

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铅、镉、汞、硒、铜和锌的单一和联合暴露与老年人的认知功能有关。

背景：接触重金属后认知功能受损已成为全球关注的重大健康问题。然而，综合暴露于多种重金属对认知功能损害的影响仍不清楚：本研究旨在探讨多种重金属暴露与认知功能之间的关系，为指导预防策略提供理论依据：方法：从2011年至2014年期间完成NHANES调查的811名美国老年人中提取血液中铅（Pb）、镉（Cd）、汞（Hg）、硒（Se）、铜（Cu）和锌（Zn）的含量以及认知功能测试结果。研究采用了量值回归（QR）、限制性立方样条（RCS）和贝叶斯核机器回归（BKMR）来探讨重金属暴露与四项标准化认知测试（项目反应理论（IRT）、延迟回忆测试（DRT）、动物流畅性测试（AFT）和数字符号替换测试（DSST））成绩之间的个体关联和联合关联：镉含量与 IRT 之间呈负相关（p = 0.048，95%CI：-2.7，-0.1）。硒浓度在 2.197 微克/升（95%CI：0.004，0.15）至 2.29 微克/升（95%CI：2.56，7.64）（log10Se）之间，与 DSST 呈正相关（p = 0.001）。铜与 DSST 呈负相关（p = 0.049，95%CI：-37.75，-0.09），而锌与 IRT 呈正相关（p = 0.022，95%CI：0.55，11.73）。6种重金属的总暴露量与IRT和DRT呈正线性关系，而与DSST呈负线性关系。镉与其他重金属（铅除外）之间存在交互作用：结论：铅、镉、汞、硒、铜和锌的暴露与认知功能有关。6 种重金属的联合暴露与 IRT 和 DRT 呈正线性关系，而与 DSST 呈负线性关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

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