C-C motif chemokine ligand 14 characterization for prediction of persistent severe AKI in post-cardiac surgery children.

IF 2.6 3区 医学 Q1 PEDIATRICS
Katie Brandewie, Jeffrey A Alten, Stuart L Goldstein, James Rose, Michael E Kim, Nicholas J Ollberding, Huaiyu Zang, Katja M Gist
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引用次数: 0

Abstract

Background: We evaluate the association of early postoperative urinary c-c motif chemokine ligand 14 (CCL14) and persistent severe acute kidney injury (AKI) in pediatric post-cardiac surgery patients.

Methods: This is a retrospective single-center cohort study of patients < 18 years of age undergoing cardiac surgery who provided a biorepository urine sample within the first 24 postoperative hours. Persistent severe AKI was defined as any AKI stage lasting for ≥ 72 h with at least one time point of AKI stage 2 or 3 during that time frame. Patients with persistent severe AKI were matched 2:1 with non-AKI patients on age and sex. Urine samples were measured for CCL14 concentration. Logistic regression was used to evaluate associations between CCL14 and persistent severe AKI.

Results: Persistent severe AKI occurred in 14 (5.4%) patients and was more common in patients with higher surgical complexity and longer cardiopulmonary bypass and cross-clamp duration. Patients with persistent severe AKI had longer median cardiac intensive care unit (CICU) (5 [3, 10] vs. 2 [1.5, 5.5], p-value = 0.039) and hospital length of stays (13.5 [7.8, 16.8] vs. 6 [4,8], p-value = 0.009). There was no difference in CCL14 levels between patients with and without persistent severe AKI (46.7 pg/ml [31.0, 82.9] vs. 44.2 pg/ml [25.1, 74.9], p-value = 0.49) in univariable and logistic regression.

Conclusions: In this heterogenous cohort of children undergoing cardiac surgery, CCL14 was not associated with persistent severe AKI. Future studies are needed to evaluate the use of CCL14 for predicting persistent severe AKI in children.

C-C motif趋化因子配体 14 的特征用于预测心脏手术后儿童持续性严重 AKI。
背景:我们评估了小儿心脏手术后患者术后早期尿液中c-c mot chemokine ligand 14(CCL14)与持续性严重急性肾损伤(AKI)的相关性:这是一项回顾性单中心队列研究,研究对象为接受心脏手术且在术后 24 小时内提供生物样本库尿样的 18 岁以下患者。持续性重度 AKI 的定义是任何 AKI 阶段持续时间≥ 72 小时,且在此期间至少有一个时间点为 AKI 阶段 2 或 3。持续性重度 AKI 患者与非 AKI 患者在年龄和性别上的配对比例为 2:1。对尿液样本进行 CCL14 浓度检测。采用逻辑回归评估 CCL14 与持续性重度 AKI 之间的关联:结果:14 例(5.4%)患者出现了持续性重度 AKI,在手术复杂度较高、心肺旁路和交叉钳夹时间较长的患者中更为常见。持续性重度 AKI 患者的心脏重症监护室(CICU)中位数(5 [3, 10] vs. 2 [1.5, 5.5],p 值 = 0.039)和住院时间(13.5 [7.8, 16.8] vs. 6 [4, 8],p 值 = 0.009)更长。在单变量和逻辑回归中,重度AKI患者和非重度AKI患者的CCL14水平没有差异(46.7 pg/ml [31.0, 82.9] vs. 44.2 pg/ml [25.1, 74.9],P值=0.49):结论:在这组接受心脏手术的异质性儿童中,CCL14与持续性严重AKI无关。未来的研究需要评估 CCL14 在预测儿童持续性重度 AKI 中的应用。
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来源期刊
Pediatric Nephrology
Pediatric Nephrology 医学-泌尿学与肾脏学
CiteScore
4.70
自引率
20.00%
发文量
465
审稿时长
1 months
期刊介绍: International Pediatric Nephrology Association Pediatric Nephrology publishes original clinical research related to acute and chronic diseases that affect renal function, blood pressure, and fluid and electrolyte disorders in children. Studies may involve medical, surgical, nutritional, physiologic, biochemical, genetic, pathologic or immunologic aspects of disease, imaging techniques or consequences of acute or chronic kidney disease. There are 12 issues per year that contain Editorial Commentaries, Reviews, Educational Reviews, Original Articles, Brief Reports, Rapid Communications, Clinical Quizzes, and Letters to the Editors.
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