Quality of bowel preparation for colonoscopy in patients on glucagon-like peptide-1 receptor agonists.

IF 6.7 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gastrointestinal endoscopy Pub Date : 2024-11-16 DOI:10.1016/j.gie.2024.11.024

Khushboo Gala, June Tome, Mary Krall, Devin Tian, John B League, Eric J Vargas, Darrell S Pardi, Amanda M Johnson, Nayantara Coelho-Prabhu

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引用次数: 0

Abstract

Background and aims: We aimed to assess the quality of bowel preparation in a matched cohort of patients actively using and not using GLP-1 RAs in a large health system in the United States.

Methods: We performed a retrospective review of adult patients undergoing colonoscopy in 22 endoscopy units across 18 sites in the US.

Results: Our cohort comprised 6235 patients (3344 cases and 2891 controls). Baseline variables causing suboptimal bowel preparation were setting of procedure (inpatient), sex (male), BMI (higher), T2D, IBD, opioid medications, heart failure, and cirrhosis. Total BBPS was significantly higher in controls even after controlling for the abovementioned variables (p < 0.01). Cases were significantly more likely to meet the definition of inadequate bowel preparation. There was no significant difference between different classes of GLP-1 RAs.

Conclusions: Patients using GLP-1 RAs are more likely to have inadequate bowel preparation during colonoscopy, even accounting for other comorbidities.

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胰高血糖素样肽-1 受体激动剂患者结肠镜检查前的肠道准备质量。

背景与目的我们旨在评估美国一个大型医疗系统中积极使用和未使用 GLP-1 RAs 的匹配队列患者的肠道准备质量：我们对在美国 18 个医疗机构的 22 个内镜室接受结肠镜检查的成年患者进行了回顾性研究：我们的队列包括 6235 名患者（3344 例病例和 2891 例对照）。导致肠道准备不足的基线变量包括手术环境（住院病人）、性别（男性）、体重指数（较高）、T2D、IBD、阿片类药物、心力衰竭和肝硬化。即使控制了上述变量，对照组的 BBPS 总值仍明显高于对照组（P < 0.01）。病例更有可能符合肠道准备不足的定义。不同类别的GLP-1 RAs之间没有明显差异：结论：即使考虑到其他合并症，使用 GLP-1 RAs 的患者在结肠镜检查期间更有可能出现肠道准备不足的情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastrointestinal endoscopy 医学-胃肠肝病学

CiteScore

10.30

自引率

7.80%

发文量

1441

审稿时长

38 days

期刊介绍： Gastrointestinal Endoscopy is a journal publishing original, peer-reviewed articles on endoscopic procedures for studying, diagnosing, and treating digestive diseases. It covers outcomes research, prospective studies, and controlled trials of new endoscopic instruments and treatment methods. The online features include full-text articles, video and audio clips, and MEDLINE links. The journal serves as an international forum for the latest developments in the specialty, offering challenging reports from authorities worldwide. It also publishes abstracts of significant articles from other clinical publications, accompanied by expert commentaries.