C-H Trifluoromethylthiolation of aldehyde hydrazones.

Abstract

The selective C-H trifluoromethylthiolation of aldehyde hydrazones afforded interesting fluorinated building blocks, which could be used as a synthetic platform. Starting from readily available (hetero)aromatic and aliphatic hydrazones, the formation of a C-SCF₃ bond was achieved under oxidative and mild reaction conditions in the presence of the readily available AgSCF₃ salt via a one-pot sequential process (28 examples, up to 91% yield). Mechanistic investigations revealed that AgSCF₃ was the active species in the transformation.