Interaction of proteinuria and diabetes on the risk of cardiovascular events: a prospective cohort CKD-ROUTE study.

IF 3.5 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

BMC Public Health Pub Date : 2024-11-18 DOI:10.1186/s12889-024-20715-2

Shahi Kishor, Jianrong Chen, Yan Zhang, Wei Liu, Lingyan Zhu, Jixiong Xu, Jiancheng Wang

{"title":"Interaction of proteinuria and diabetes on the risk of cardiovascular events: a prospective cohort CKD-ROUTE study.","authors":"Shahi Kishor, Jianrong Chen, Yan Zhang, Wei Liu, Lingyan Zhu, Jixiong Xu, Jiancheng Wang","doi":"10.1186/s12889-024-20715-2","DOIUrl":null,"url":null,"abstract":"Objective: We evaluated the interaction of urinary protein-to-creatinine ratio (UPCR) with diabetes on the risk of cardiovascular events in a cohort study.Methods: The study population consisted of 639 participants with chronic kidney disease (CKD) stages 2-5, enrolled between 2010 and 2011 in Japan. Cox proportional hazards models were used to evaluate the independent and combined effects of the UPCR and diabetes on cardiovascular events.Results: During a median follow-up of 3 years, 59 participants developed cardiovascular events during follow-up. A notably higher risk of cardiovascular events was found in participants with proteinuria [hazards ratio (HR): 2.16, 95% confidence interval (95% CI): 1.17-3.97] compared to those without proteinuria at UPCR levels. In addition, the participants with diabetes had a higher risk of cardiovascular events (HR: 2.53, 95% CI: 1.49-4.30) than those without diabetes. Moreover, an interaction was found between UPCR and diabetes on cardiovascular events (P for interaction = 0.04). Participants with both proteinuria (UPCR ≥ 0.5 g/gCr) and diabetes had a 4.09 times higher risk of cardiovascular events (HR: 4.09, 95% CI: 1.97-8.47) compared with those without proteinuria (UPCR < 0.5 g/gCr) and diabetes.Conclusions: In summary, among participants with CKD stages 2-5, proteinuria and diabetes were found to independently and jointly affect the risk of cardiovascular events. Participants with proteinuria and diabetes had the highest risk of cardiovascular events compared with other groups.","PeriodicalId":9039,"journal":{"name":"BMC Public Health","volume":"24 1","pages":"3192"},"PeriodicalIF":3.5000,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572061/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Public Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12889-024-20715-2","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: We evaluated the interaction of urinary protein-to-creatinine ratio (UPCR) with diabetes on the risk of cardiovascular events in a cohort study.

Methods: The study population consisted of 639 participants with chronic kidney disease (CKD) stages 2-5, enrolled between 2010 and 2011 in Japan. Cox proportional hazards models were used to evaluate the independent and combined effects of the UPCR and diabetes on cardiovascular events.

Results: During a median follow-up of 3 years, 59 participants developed cardiovascular events during follow-up. A notably higher risk of cardiovascular events was found in participants with proteinuria [hazards ratio (HR): 2.16, 95% confidence interval (95% CI): 1.17-3.97] compared to those without proteinuria at UPCR levels. In addition, the participants with diabetes had a higher risk of cardiovascular events (HR: 2.53, 95% CI: 1.49-4.30) than those without diabetes. Moreover, an interaction was found between UPCR and diabetes on cardiovascular events (P for interaction = 0.04). Participants with both proteinuria (UPCR ≥ 0.5 g/gCr) and diabetes had a 4.09 times higher risk of cardiovascular events (HR: 4.09, 95% CI: 1.97-8.47) compared with those without proteinuria (UPCR < 0.5 g/gCr) and diabetes.

Conclusions: In summary, among participants with CKD stages 2-5, proteinuria and diabetes were found to independently and jointly affect the risk of cardiovascular events. Participants with proteinuria and diabetes had the highest risk of cardiovascular events compared with other groups.

查看原文本刊更多论文

蛋白尿和糖尿病对心血管事件风险的相互作用：一项前瞻性队列 CKD-ROUTE 研究。

目的我们在一项队列研究中评估了尿蛋白肌酐比值（UPCR）与糖尿病对心血管事件风险的相互影响：研究对象包括 639 名慢性肾脏病 (CKD) 2-5 期患者，他们于 2010 年至 2011 年期间在日本注册。研究采用Cox比例危险模型评估UPCR和糖尿病对心血管事件的独立影响和联合影响：结果：在中位 3 年的随访期间，59 名参与者发生了心血管事件。在 UPCR 水平下，与无蛋白尿者相比，有蛋白尿者发生心血管事件的风险明显更高[危险比（HR）：2.16，95% 置信区间（95% CI）：1.17-3.97]。此外，患有糖尿病的参与者发生心血管事件的风险（HR：2.53，95% 置信区间：1.49-4.30）高于未患糖尿病的参与者。此外，UPCR 和糖尿病对心血管事件的影响存在交互作用（交互作用的 P = 0.04）。同时患有蛋白尿（UPCR ≥ 0.5 g/gCr）和糖尿病的参与者发生心血管事件的风险是无蛋白尿者的 4.09 倍（HR：4.09，95% CI：1.97-8.47）：总之，在患有慢性肾脏病 2-5 期的参与者中，发现蛋白尿和糖尿病会独立并共同影响心血管事件的风险。与其他组别相比，蛋白尿和糖尿病患者发生心血管事件的风险最高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

4.40%

发文量

2108

审稿时长

1 months

期刊介绍： BMC Public Health is an open access, peer-reviewed journal that considers articles on the epidemiology of disease and the understanding of all aspects of public health. The journal has a special focus on the social determinants of health, the environmental, behavioral, and occupational correlates of health and disease, and the impact of health policies, practices and interventions on the community.