Hydrogels Based on Polyelectrolyte Complexes: Underlying Principles and Biomedical Applications.

IF 5.5 2区 化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-18 DOI:10.1021/acs.biomac.4c01240
Belynn Sim, Jun Jie Chang, Qianyu Lin, Joey Hui Min Wong, Valerie Ow, Yihao Leow, Yi Jing Wong, Yi Jian Boo, Rubayn Goh, Xian Jun Loh
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引用次数: 0

Abstract

Ionic complexes of electrostatically charged biomacromolecules are key players in various biological processes like nucleotide transportation, organelle formation, and protein folding. These complexes, abundant in biological systems, contribute to the function, responsiveness, and mechanical properties of organisms. Coherent with these natural phenomena, hydrogels formed through the complexation of oppositely charged polymers exhibit unique attributes, such as rapid self-assembly, hierarchical microstructures, tunable properties, and protective encapsulation. Consequently, polyelectrolyte complex (PEC) hydrogels have garnered considerable interest, emerging as an up-and-coming platform for various biomedical applications. This review outlines the underlying principles governing PEC hydrogels. The classification of polyelectrolytes and the self-assembly of PEC hydrogels are discussed, including the factors influencing their self-assembly process. Recent developments of PEC hydrogels for biomedical applications, including drug delivery, tissue engineering, wound healing and management, and wearable sensors, are summarized. This review concludes with the prospective directions for the next generation of PEC hydrogel research.

基于聚电解质复合物的水凝胶:基本原理和生物医学应用。
带静电的生物大分子的离子复合物是核苷酸运输、细胞器形成和蛋白质折叠等各种生物过程的关键角色。这些复合物在生物系统中含量丰富,有助于提高生物体的功能、反应能力和机械特性。与这些自然现象相一致,通过带相反电荷的聚合物复合物形成的水凝胶也表现出独特的特性,如快速自组装、分层微结构、可调特性和保护性封装。因此,聚电解质复合物(PEC)水凝胶引起了人们的极大兴趣,成为各种生物医学应用的新兴平台。本综述概述了 PEC 水凝胶的基本原理。文章讨论了聚电解质的分类和 PEC 水凝胶的自组装,包括影响其自组装过程的因素。综述了 PEC 水凝胶在生物医学应用方面的最新进展,包括药物输送、组织工程、伤口愈合和管理以及可穿戴传感器。本综述最后提出了下一代 PEC 水凝胶研究的前景方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomacromolecules
Biomacromolecules 化学-高分子科学
CiteScore
10.60
自引率
4.80%
发文量
417
审稿时长
1.6 months
期刊介绍: Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.
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