Coexposure to ambient air pollution and temperature and its associations with birth outcomes in women undergoing assisted reproductive technology in Fujian, China: A retrospective cohort study

IF 12.2 1区环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL

Journal of Hazardous Materials Pub Date : 2024-11-17 DOI:10.1016/j.jhazmat.2024.136539

Dongdong Jiang, Xuefen Cai, Hua Fang, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Wenxiang Wang, Yan Sun

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Abstract

Background

The interactions between pollutants and temperature coexposure, the mixing effects and their potential mechanisms remain uncertain.

Methods

This retrospective cohort study included 11,766 women with infertility who received treatment at Fujian Hospital between 2015 and 2024. The daily mean concentrations of the six pollutants and the relative humidity and temperature data were acquired from the Fujian region. Data on genes were obtained from the Comparative Toxicogenomics Database.

Results

O₃ (aOR=0.80, 95% CI=0.725--0.891) and temperature (aOR=0.936, 95% CI=0.916--0.957) were negatively correlated with live birth rates. Moreover, PM₁₀ (aOR=1.135, 95% CI=1.028--1.252) and PM_2.5 (aOR=1.146, 95% CI=1.03--1.274) were positively associated with preterm birth. Among the effects on live births, PM_2.5, PM₁₀, NO₂, CO, and SO₂ had significant synergistic effects with temperature; in addition, O₃ had significant antagonistic effects with temperature. A notable trend toward declining live birth rates with elevated concentrations of mixed pollutants was observed. Different infertility patients have different sensitivities to coexposure. Gene enrichment and cell experiments are associated mainly with cellular life activities.

Conclusions

Individual effects, interactions, and mixed effects between temperature and air pollutants and birth outcomes persist when air pollutant levels are relatively low. AAP may trigger miscarriage through cytotoxic effects.

Abstract Image

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中国福建接受辅助生殖技术的妇女对环境空气污染和温度的共同暴露及其与生育结果的关系：一项回顾性队列研究

方法这项回顾性队列研究纳入了2015年至2024年间在福建医院接受治疗的11766名不孕症妇女。六种污染物的日平均浓度以及相对湿度和温度数据均来自福建地区。结果O3（aOR=0.80，95% CI=0.725--0.891）和温度（aOR=0.936，95% CI=0.916--0.957）与活产率呈负相关。此外，PM10（aOR=1.135，95% CI=1.028--1.252）和 PM2.5（aOR=1.146，95% CI=1.03--1.274）与早产呈正相关。在对活产的影响中，PM2.5、PM10、二氧化氮、一氧化碳和二氧化硫与温度有显著的协同效应；此外，臭氧与温度有显著的拮抗效应。随着混合污染物浓度的升高，活产率呈明显下降趋势。不同的不孕症患者对共暴露的敏感性不同。结论当空气污染物水平相对较低时，温度和空气污染物与出生结果之间仍然存在个体效应、相互作用和混合效应。空气污染物可能通过细胞毒性效应引发流产。

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来源期刊

Journal of Hazardous Materials 工程技术-工程：环境

CiteScore

25.40

自引率

5.90%

发文量

3059

审稿时长

58 days

期刊介绍： The Journal of Hazardous Materials serves as a global platform for promoting cutting-edge research in the field of Environmental Science and Engineering. Our publication features a wide range of articles, including full-length research papers, review articles, and perspectives, with the aim of enhancing our understanding of the dangers and risks associated with various materials concerning public health and the environment. It is important to note that the term "environmental contaminants" refers specifically to substances that pose hazardous effects through contamination, while excluding those that do not have such impacts on the environment or human health. Moreover, we emphasize the distinction between wastes and hazardous materials in order to provide further clarity on the scope of the journal. We have a keen interest in exploring specific compounds and microbial agents that have adverse effects on the environment.