Front Cover: Uracil-Selective Cross-Linking in RNA and Inhibition of miRNA Function by 2-Amino-6-vinyl-7-deazapurine Deoxynucleosides (ChemBioChem 21/2024)
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Abstract
MicroRNAs (miRNAs) regulate gene expression through RNA interference. Consequently, miRNA inhibitors, such as anti-miRNA oligonucleotides (AMOs), have attracted attention for treating miRNA overexpression. In article 10.1002/cbic.202400417, Fumi Nagatsugi and co-workers demonstrate that the cross-linkable nucleoside (2-amino-7-deaza-7-propynyl-6-vinylpurine deoxyriboside; dADpVP) reacted to counter uridine with high reactivity upon duplex hybridization. Moreover, the oligonucleotide containing dADpVP targeting the miRNA binding site in mRNA 3′UTR effectively inhibit the miR21 function in cells by covalent formation.
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ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
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