Cu-Bi2S3 nanorods promote reactive oxygen species production for photodynamic therapy of prostate cancer

IF 7.1 3区材料科学 Q1 GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY

Materials Today Sustainability Pub Date : 2024-11-14 DOI:10.1016/j.mtsust.2024.101047

Jiacheng Ling , Rongrong Gu , Junchao Wu , Hualong Li , Yuanxi Lin , Yang Hou , Xiaoyi Huang , Ruixi Chu , Tao Xu , Sheng Ye , Song Fan

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Abstract

Photodynamic therapy (PDT) has emerged as a promising cancer treatment approach due to its non-invasive and specifically targeted nature. However, the effectiveness of PDT is hindered by the complex synthesis of conventional photosensitizers and inadequate reactive oxygen species (ROS) generation. Here, we synthesize a copper-doped Bi₂S₃ (Cu-Bi₂S₃) nanorod to investigate its PDT potential against PCa. Compared with bulk Bi₂S₃ (58%), Cu-Bi₂S₃ nanorod caused 87% of PC3 cells to die under light. The dispersed Cu in the Bi₂S₃ bulk phase effectively inhibits the recombination of photogenerated electron-hole pairs, ultimately providing a high concentration of charge carriers. DFT calculations show that Cu doping causes the d-band center of Cu-Bi₂S₃, promoting the adsorption and activation of O₂ on Cu-Bi₂S₃ to enhance ROS generation. This work offers a viable solution to the pressing scientific challenge of ROS generation, a key aspect of enhancing the efficacy of PDT for cancer treatment.

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铜-Bi2S3 纳米棒促进活性氧生成，用于前列腺癌的光动力疗法

光动力疗法（PDT）因其无创伤和针对性强的特点，已成为一种前景广阔的癌症治疗方法。然而，传统光敏剂的复杂合成和活性氧（ROS）生成不足阻碍了光动力疗法的有效性。在这里，我们合成了一种掺铜的 Bi2S3（Cu-Bi2S3）纳米棒，以研究它对 PCa 的局部放疗潜力。与块状 Bi2S3（58%）相比，Cu-Bi2S3 纳米棒能使 87% 的 PC3 细胞在光照下死亡。Bi2S3体相中分散的铜有效抑制了光生电子-空穴对的重组，最终提供了高浓度的电荷载流子。DFT 计算表明，Cu 掺杂会导致 Cu-Bi2S3 的 d 带中心，促进 O2 在 Cu-Bi2S3 上的吸附和活化，从而增强 ROS 的生成。这项工作为 ROS 生成这一紧迫的科学挑战提供了可行的解决方案，而 ROS 生成是提高光导放疗（PDT）治疗癌症疗效的一个关键方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Today Sustainability Multiple-

CiteScore

5.80

自引率

6.40%

发文量

174

审稿时长

32 days

期刊介绍： Materials Today Sustainability is a multi-disciplinary journal covering all aspects of sustainability through materials science. With a rapidly increasing population with growing demands, materials science has emerged as a critical discipline toward protecting of the environment and ensuring the long term survival of future generations.