Two hispidin dimers from Piptoporellus baudonii (Fomitopsidaceae) with anticancer activity

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-11-15 DOI:10.1016/j.phytol.2024.11.002

Jenifer Reine Ngnouzouba Kuete , Olyvia Gwladys Fadeyi , Boris Armel Olou , Frank Wilson Tiatsop Kenmoe , Bienvenu Tsakem , Rémy Bertrand Teponno , Léon Azefack Tapondjou , Simeon Fogue Kouam , Nourou Soulemane Yorou

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Abstract

Chemical analysis of the ethanol extract from the stromata of Piptoporellus baudonii led to the isolation and characterization of two unreported bishispidin derivatives named 11-hydroxysquarrosidine (1) and laetipohispidin (2) together with two known terpenoids: ergosterol (3) and eburicoic acid (4). Their structures were elucidated by spectroscopic methods including 1D and 2D NMR, UV, IR, ECD as well as the high-resolution mass spectrometry. Although metabolite 1 was reported in a patent as a synthetic compound, this is the first report on its isolation from natural source. Compounds 1 and 2 were evaluated for their antimicrobial and cytotoxic activities. 11-hydroxysquarrosidine (1) exhibited a moderate activity against all the tested human cancer cell lines with IC₅₀ values ranging from 25.79 to 73.41 µM.

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具有抗癌活性的 Piptoporellus baudonii（Fomitopsidaceae）中的两种糙二丁二聚体

通过对从包龙柏（Piptoporellus baudonii）叠层中提取的乙醇进行化学分析，分离并鉴定了两种未报道的双鱼苷衍生物（11-hydroxysquarrosidine (1)和 laetipohispidin (2)）以及两种已知的萜类化合物：麦角甾醇（ergosterol (3)）和桉叶油酸（enburicoic acid (4)）。它们的结构是通过光谱方法（包括一维和二维核磁共振、紫外光谱、红外光谱、电子串联质谱以及高分辨率质谱）阐明的。虽然代谢物 1 曾作为合成化合物在专利中报道过，但这是首次从天然来源中分离出代谢物 1 的报道。对化合物 1 和 2 的抗菌和细胞毒性活性进行了评估。11-hydroxysquarrosidine (1) 对所有测试的人类癌细胞株都表现出中等程度的活性，IC50 值介于 25.79 到 73.41 µM 之间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.