Evaluation of the effects of a Chinese herb in nonoperative bone fractures in Taiwan: a retrospective multi-central database cohort study

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine Pub Date : 2024-10-18 DOI:10.1016/j.hermed.2024.100956

Chung-Yuan Hsu , Shin-Yu Huang , Wei-Jen Cheng

{"title":"Evaluation of the effects of a Chinese herb in nonoperative bone fractures in Taiwan: a retrospective multi-central database cohort study","authors":"Chung-Yuan Hsu , Shin-Yu Huang , Wei-Jen Cheng","doi":"10.1016/j.hermed.2024.100956","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Bone fracture is a critical issue worldwide, affecting daily activities and increasing living expenses. The effect of Chinese herbs on bone union has been evaluated in recent years. However, its clinical efficacy in the unionisation of bone fractures is not completely elucidated. Zheng-Gu-Zi-Jin-Dang (ZGZJD) is a famous formula in Chinese medicine traumatology that has been widely used in patients with fractures in previous studies.</div></div><div><h3>Methods</h3><div>We used the Chang Gung Research Database and retrospectively reviewed patients at Chang Gung Memorial Hospital who suffered from bone fractures to evaluate the efficacy of ZGZJD intervention on bone union within 3 months after bone fractures and we used the frequency matching method in a 1:5 ratio for further analysis.</div></div><div><h3>Results</h3><div>Between 2004 and 2016, 291851 fractures were diagnosed at Chang Gung Memorial Hospital. A total of 544 patients received ZGZJD, and 2720 patients were match as control which do not use the herbs. However, we adjusted the comorbidities affecting the bone union, sex, age and different body extremities and there were no better healing rate in ZGZJD patient.</div></div><div><h3>Conclusions</h3><div>Although ZGZJD is a common formula used in bone fractures, there is no direct clinical evidence that it enhances bone union. However, according to ingredients analysis in ZGZJD, this famous Chinese traumatology medicine may be useful during the inflammatory phase of bone healing.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100956"},"PeriodicalIF":2.2000,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Herbal Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210803324001131","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

Bone fracture is a critical issue worldwide, affecting daily activities and increasing living expenses. The effect of Chinese herbs on bone union has been evaluated in recent years. However, its clinical efficacy in the unionisation of bone fractures is not completely elucidated. Zheng-Gu-Zi-Jin-Dang (ZGZJD) is a famous formula in Chinese medicine traumatology that has been widely used in patients with fractures in previous studies.

Methods

We used the Chang Gung Research Database and retrospectively reviewed patients at Chang Gung Memorial Hospital who suffered from bone fractures to evaluate the efficacy of ZGZJD intervention on bone union within 3 months after bone fractures and we used the frequency matching method in a 1:5 ratio for further analysis.

Results

Between 2004 and 2016, 291 851 fractures were diagnosed at Chang Gung Memorial Hospital. A total of 544 patients received ZGZJD, and 2 720 patients were match as control which do not use the herbs. However, we adjusted the comorbidities affecting the bone union, sex, age and different body extremities and there were no better healing rate in ZGZJD patient.

Conclusions

Although ZGZJD is a common formula used in bone fractures, there is no direct clinical evidence that it enhances bone union. However, according to ingredients analysis in ZGZJD, this famous Chinese traumatology medicine may be useful during the inflammatory phase of bone healing.

查看原文本刊更多论文

台湾非手术骨折患者服用中草药效果的评估：一项回顾性多中心数据库队列研究

导言：骨折是世界范围内的一个严重问题，影响日常活动并增加生活费用。近年来，人们对中草药对骨结合的影响进行了评估。然而，中药对骨折愈合的临床疗效尚未完全阐明。正桂紫金丹是中医伤科名方，在以往的研究中被广泛应用于骨折患者。方法我们利用长庚研究数据库，对长庚纪念医院的骨折患者进行回顾性研究，评估正桂紫金丹干预对骨折后3个月内骨结合的疗效，并采用频率匹配法以1:5的比例进行进一步分析。结果2004年至2016年间，长庚纪念医院共确诊291 851例骨折患者。共有 544 名患者接受了 ZGZJD 治疗，另有 2 720 名患者作为未使用中草药的对照组。结论虽然 ZGZJD 是治疗骨折的常用配方，但没有直接的临床证据表明它能促进骨结合。然而，根据 ZGZJD 的成分分析，这种著名的中药在骨愈合的炎症阶段可能会有用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Herbal Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.