Synthesis of prodelphinidin B2 3,3′′-digallate using AgOTf-mediated self-condensation

Abstract

The Lewis acid mediated self-condensation of an epigallocatechin gallate derivative was examined. We found that AgOTf as a Lewis acid and diethylene glycol as a leaving group at C-4 position afforded a dimeric epigallocatechin gallate derivative in a moderate yield. The condensed product was applied to the synthesis of prodelphinidin B2 3,3′′-digallate.