A high-water retention, self-healing hydrogel thyroid model for surgical training

IF 8.7 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Liang Ma , Zhihao Zhu , Shijie Yu , Sidney Moses Amadi , Fei Zhao , Jing Zhang , Zhifei Wang
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Abstract

The evaluation of thyroid lesions through Fine-Needle Aspiration Biopsy (FNAB) is a common procedure that requires advanced hand manipulation skills. Conventional training models for this procedure lack essential features such as tactile sensation and the ability to repeat punctures similar to those of real organs. To improve the quality of training, we have developed a hydrogel thyroid model that possesses features such as high-water retention and self-healing properties. This model consists of polyvinyl alcohol (PVA), polyacrylic acid (PAA), and trehalose that enhance water retention. By utilizing indirect printing technology, this hydrogel-based thyroid model closely resembles those of porcine thyroid tissue in terms of compression modulus and friction coefficient, exhibiting exceptional conformability, flexibility, and a water retention rate of 94.7 % at 6 h. It also displays a thrust force range of 0–0.98 N during simulated puncture, closely approximating real FNAB operations. This model shows evidence that it effectively simulates thyroid tissue and can be utilized for repetitive FNAB training to enhance the proficiency of medical personnel. Our study focuses on introducing new possibilities for developing advanced materials training models to be utilized in the medical field.

Abstract Image

用于外科手术训练的高保水、自愈合水凝胶甲状腺模型
通过细针抽吸活检(FNAB)评估甲状腺病变是一种常见的手术,需要高级的手部操作技能。该手术的传统训练模型缺乏基本特征,如触觉和重复类似真实器官穿刺的能力。为了提高培训质量,我们开发了一种水凝胶甲状腺模型,它具有高保水和自愈合特性。该模型由聚乙烯醇(PVA)、聚丙烯酸(PAA)和可增强保水性的树胶糖组成。通过采用间接打印技术,这种基于水凝胶的甲状腺模型在压缩模量和摩擦系数方面与猪甲状腺组织非常相似,表现出卓越的保形性和柔韧性,6 小时后的保水率达到 94.7%,而且在模拟穿刺过程中显示出 0-0.98 N 的推力范围,非常接近真实的 FNAB 操作。有证据表明,该模型能有效模拟甲状腺组织,可用于重复性 FNAB 培训,以提高医务人员的熟练程度。我们的研究重点在于为医学领域开发先进的材料培训模型提供新的可能性。
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来源期刊
CiteScore
8.30
自引率
4.90%
发文量
303
审稿时长
30 days
期刊介绍: Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).
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