Pure organic phosphorescent scintillator for glucose metabolism regulation-enhanced low-dose X-ray-induced photodynamic therapy

IF 13.2 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Xiaoyu Zhang , Yating Wen , Baojie Du , Yating Huang , Yunxiang Liu , Rong Zhang , Liping Li , Ruiping Zhang
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引用次数: 0

Abstract

X-ray-induced photodynamic therapy (X-PDT) leverages the penetration power of X-rays to generate reactive oxygen species (ROS) within deep tissues for cancer treatment, merging the benefits of both photodynamic therapy and radiotherapy. Traditional X-PDT, however, typically relies on inorganic scintillators containing heavy-metals to act as energy transducers, exciting nearby photosensitizers to produce singlet oxygen. Moreover, the hypoxia conditions prevalent in tumors can severely diminish the efficacy of X-PDT. Here, we report a metal-free, self-enhanced organic phosphorescent nanoscintillator (termed OPSG NPs) capable of efficiently generating singlet oxygen under low-dose X-ray irradiation, facilitated by glucose metabolism regulation. OPSG NPs are constructed through a self-assembly behavior driven by molecular interactions between an organic phosphorescent scintillator and a glucose transporter 1 (GLUT1) inhibitor. The OPSG NPs serve dual functions, acting as both scintillator and photosensitizer, which can be activated by direct X-ray irradiation. Additionally, they possess the ability to inhibit glucose supply and reduce oxygen consumption for tumor cell respiration. This strategy effectively alleviates the hypoxia within the tumor microenvironment and consequently enhances the therapeutic efficacy of X-PDT. Both in vitro and in vivo studies demonstrate the excellent antitumor X-PDT performance. This glucose metabolism regulation-enhanced low-dose X-PDT strategy paves the way for more efficient therapy against deep-seated tumors.
用于葡萄糖代谢调节增强型低剂量 X 射线诱导光动力疗法的纯有机磷光闪烁体
X 射线诱导的光动力疗法(X-PDT)利用 X 射线的穿透力在深层组织内产生活性氧(ROS)来治疗癌症,融合了光动力疗法和放射疗法的优点。然而,传统的 X-PDT 通常依赖含有重金属的无机闪烁体作为能量转换器,激发附近的光敏剂产生单线态氧。此外,肿瘤中普遍存在的缺氧条件会严重削弱 X-PDT 的功效。在此,我们报告了一种无金属、自增强的有机磷光纳米闪烁体(称为 OPSG NPs),它能在低剂量 X 射线照射下有效地产生单线态氧,并能通过葡萄糖代谢调节发挥作用。OPSG NPs 是通过有机磷光闪烁体和葡萄糖转运体 1(GLUT1)抑制剂之间的分子相互作用驱动的自组装行为构建的。OPSG NPs 具有双重功能,既是闪烁体又是光敏剂,可通过直接 X 射线照射激活。此外,它们还具有抑制葡萄糖供应和减少肿瘤细胞呼吸耗氧量的能力。这种策略能有效缓解肿瘤微环境中的缺氧状况,从而提高 X-PDT 的疗效。体外和体内研究都证明了 X-PDT 卓越的抗肿瘤性能。这种葡萄糖代谢调节增强型低剂量 X-PDT 策略为更有效地治疗深部肿瘤铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nano Today
Nano Today 工程技术-材料科学:综合
CiteScore
21.50
自引率
3.40%
发文量
305
审稿时长
40 days
期刊介绍: Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.
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