The shared neurobiological basis of developmental dyslexia and developmental stuttering: A meta-analysis of functional and structural MRI studies

IF 5.3 1区心理学 Q1 PSYCHOLOGY, CLINICAL

International Journal of Clinical and Health Psychology Pub Date : 2024-10-01 DOI:10.1016/j.ijchp.2024.100519

Huan Ren , Yi zhen Li , Hong-Yan Bi , Yang Yang

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引用次数: 0

Abstract

Background

Developmental dyslexia (DD) and persistent developmental stuttering (PDS) are the most representative written and spoken language disorders, respectively, and both significantly hinder life success. Although widespread brain alterations are evident in both DD and PDS, it remains unclear to what extent these two language disorders share common neural substrates.

Methods

A systematic review and meta-analysis of task-based functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM) studies of PDS and DD were conducted to explore the shared functional and anatomical alterations across these disorders.

Results

The results of fMRI studies indicated shared hypoactivation in the left inferior temporal gyrus and inferior parietal gyrus across PDS and DD compared to healthy controls. When examined separately for children and adults, we found that child participants exhibited reduced activation in the left inferior temporal gyrus, inferior parietal gyrus, precentral gyrus, middle temporal gyrus, and inferior frontal gyrus, possibly reflecting the universal causes of written and spoken language disorders. In contrast, adult participants exhibited hyperactivation in the right precentral gyrus and left cingulate motor cortex, possibly reflecting common compensatory mechanisms. Anatomically, the analysis of VBM studies revealed decreased gray matter volume in the left inferior frontal gyrus across DD and PDS, which was exclusively observed in children. Finally, meta-analytic connectivity modeling and brain-behavior correlation analyses were conducted to explore functional connectivity patterns and related cognitive functions of the brain regions commonly involved in DD and PDS.

Conclusions

This study identified concordances in brain abnormalities across DD and PDS, suggesting common neural substrates for written and spoken language disorders and providing new insights into the transdiagnostic neural signatures of language disorders.

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发育性阅读障碍和发育性口吃的共同神经生物学基础：功能性和结构性核磁共振成像研究的荟萃分析

背景发育性诵读困难（DD）和持续性发育性口吃（PDS）分别是最具代表性的书面和口语语言障碍，两者都严重阻碍了人生的成功。方法对基于任务的功能磁共振成像（fMRI）和基于体素的形态测量（VBM）研究进行了系统回顾和荟萃分析，以探讨发育性阅读障碍和持续性发育性口吃的共同功能和解剖学改变。结果fMRI研究结果表明，与健康对照组相比，PDS和DD患者的左侧颞下回和顶叶下回存在共同的低激活现象。在对儿童和成人进行分别检查时，我们发现儿童参与者的左侧颞下回、顶叶下回、前中央回、颞中回和额下回的激活减少，这可能反映了书面和口语障碍的普遍原因。相比之下，成年参与者的右侧中央前回和左侧扣带运动皮层则表现出过度激活，这可能反映了共同的补偿机制。从解剖学角度看，VBM 研究分析表明，DD 和 PDS 患者的左侧额叶下回灰质体积减少，而这只在儿童中观察到。最后，研究人员还进行了元分析连接建模和大脑行为相关性分析，以探讨DD和PDS常见脑区的功能连接模式和相关认知功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Clinical and Health Psychology PSYCHOLOGY, CLINICAL-

CiteScore

10.70

自引率

5.70%

发文量

审稿时长

33 days

期刊介绍： The International Journal of Clinical and Health Psychology is dedicated to publishing manuscripts with a strong emphasis on both basic and applied research, encompassing experimental, clinical, and theoretical contributions that advance the fields of Clinical and Health Psychology. With a focus on four core domains—clinical psychology and psychotherapy, psychopathology, health psychology, and clinical neurosciences—the IJCHP seeks to provide a comprehensive platform for scholarly discourse and innovation. The journal accepts Original Articles (empirical studies) and Review Articles. Manuscripts submitted to IJCHP should be original and not previously published or under consideration elsewhere. All signing authors must unanimously agree on the submitted version of the manuscript. By submitting their work, authors agree to transfer their copyrights to the Journal for the duration of the editorial process.