A digital tool for multidimensional assessment and prediction of treatment effectiveness in chronic pain management

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2024-10-18 DOI:10.1016/j.isci.2024.111200

Philippe Rigoard , Amine Ounajim , Maarten Moens , Lisa Goudman , Manuel Roulaud , Nicolas Naiditch , Raouf Boukenna , Philippe Page , Bénédicte Bouche , Bertille Lorgeoux , Sandrine Baron , Kevin Nivole , Mathilde Many , Lucie Lampert , Géraldine Brumauld de Montgazon , Brigitte Roy-Moreau , Romain David , Maxime Billot

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Abstract

Given the multidimensional aspect of pain, the assessment of treatment efficacy is challenging. The prospective observational multicenter PREDIBACK study aimed to assess, compare, and predict the effectiveness of different treatments for persistent spinal pain syndrome type 2 (PSPS-T2) using a digital tool and the Multidimensional Clinical Response Index (MCRI) including pain intensity, functional disability, quality of life, anxiety and depression, and pain surface. Results indicated that neurostimulation was the most effective treatment at 3-, 6-, 9-, and 12-month follow-up compared to baseline, leading to significant improvements in pain, function, and quality of life, whereas optimized medical management (OMM) and spinal reoperation showed no significant benefits. Additionally, the study identified pain surface, BMI, and smoking status as predictors of treatment outcomes. These findings highlight the potential of digital medicine to improve patient care by providing data-driven insights and personalized treatment recommendations for PSPS-T2.

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用于多维评估和预测慢性疼痛治疗效果的数字化工具

鉴于疼痛的多维性，对治疗效果的评估具有挑战性。前瞻性多中心观察性 PREDIBACK 研究旨在使用数字工具和多维临床反应指数（MCRI）（包括疼痛强度、功能障碍、生活质量、焦虑和抑郁以及疼痛表面）评估、比较和预测不同治疗方法对持续性脊柱疼痛综合征 2 型（PSPS-T2）的疗效。结果表明，与基线相比，神经刺激是随访 3 个月、6 个月、9 个月和 12 个月时最有效的治疗方法，可显著改善疼痛、功能和生活质量，而优化医疗管理 (OMM) 和脊柱再手术则无明显疗效。此外，该研究还发现疼痛表面、体重指数和吸烟状况是预测治疗结果的因素。这些发现凸显了数字医学通过提供数据驱动的见解和针对 PSPS-T2 的个性化治疗建议来改善患者护理的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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