Dietary or pharmacological inhibition of insulin-like growth factor-1 protects from renal ischemia-reperfusion injury in mice

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2024-10-28 DOI:10.1016/j.isci.2024.111256

Arnaud Lyon , Thomas Agius , Michael R. Macarthur , Kevin Kiesworo , Louis Stavart , Florent Allagnat , Sarah J. Mitchell , Leonardo V. Riella , Korkut Uygun , Heidi Yeh , Sebastien Déglise , Déla Golshayan , Alban Longchamp

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引用次数: 0

Abstract

One-week protein restriction (PR) limits ischemia-reperfusion (IR) damages and improves metabolic fitness. Similarly, longer-term calory restriction results in increased lifespan, partly via reduced insulin-like growth factor (IGF)-1. However, the influence of short-term PR on IGF-1 and its impact on IR are unknown. PR was achieved in mice via one-week carbohydrate loading and/or through a low-protein diet. PR decreased IGF-1 circulating levels as well as renal and hepatic expression. Upon renal IR, serum IGF-1 positively correlated with renal dysfunction and tissular damages, independently of sex and age. Exogenous IGF-1 administration abrogated PR benefits during IR, while IGF-1 receptor inhibition with linsitinib was protective. IGF-1 was associated with a reduction in forkhead box O (FoxO), and AMP-activated protein kinase (AMPK) signaling pathways previously demonstrated to improve IR resilience in various organs. These data support dietary or pharmacological reduction of IGF-1 signaling to mitigate IR injury prior to solid organ transplantation and beyond.

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膳食或药物抑制胰岛素样生长因子-1可防止小鼠肾缺血再灌注损伤

为期一周的蛋白质限制（PR）可限制缺血再灌注（IR）损伤并改善代谢健康。同样，长期热量限制会延长寿命，部分原因是胰岛素样生长因子（IGF）-1 减少。然而，短期PR对IGF-1的影响及其对IR的影响尚不清楚。小鼠通过一周的碳水化合物负荷和/或低蛋白饮食来实现 PR。PR降低了IGF-1的循环水平以及肾脏和肝脏表达。肾脏IR时，血清IGF-1与肾功能障碍和组织损伤呈正相关，与性别和年龄无关。服用外源性IGF-1会减弱IR期间的PR益处，而使用林西替尼抑制IGF-1受体则具有保护作用。IGF-1与叉头框O（FoxO）和AMP激活蛋白激酶（AMPK）信号通路的减少有关，这些信号通路以前曾被证明能提高各种器官的红外适应能力。这些数据支持通过饮食或药物减少 IGF-1 信号传导，以减轻实体器官移植前和移植后的红外损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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