Regional analysis and stage-specific incidence of breast cancer in Kazakhstan: A comprehensive study

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2024-11-01 DOI:10.1016/j.cegh.2024.101837

Nurbek Igissin , Assem Toguzbayeva , Zhansaya Telmanova , Gulnur Igissinova , Dulat Turebayev , Dariyana Kulmirzayeva , Nariman Syzdykov , Rustem Moldagali , Daulet Baibosynov , Zarina Bilyalova

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引用次数: 0

Abstract

Background

Breast cancer is the most prevalent oncological pathology in Kazakhstan, ranking among the top three causes of cancer-related deaths in women. The objective of this study is to analyze the incidence of breast cancer, considering factors such as stage, age, sex, and morphological verification in the regional context in Kazakhstan.

Methods

The retrospective study employed descriptive and analytical oncoepidemiological methods. Breast cancer incidence data (2005–2019) were obtained from the Unified Nationwide Electronic Health System (ICD-10 code C50). Demographic data came from the Bureau of National Statistics. Statistical analyses included age-standardized, crude, and age-specific incidence rates, with trend analyses performed using linear regression and the Joinpoint Regression Program to assess average percentage change over time.

Results

The analysis of breast cancer incidence in Kazakhstan shows significant regional variations and an overall upward trend. Nationally, the age-standardized incidence rate is 40.9 per 100,000, with an annual increase of +1.96 %. Early-stage (I-II) breast cancer incidence is rising, particularly in Pavlodar, North Kazakhstan, and Almaty City. In contrast, advanced-stage (III-IV) incidence has generally declined, except in regions like Kostanay, North Kazakhstan, and Atyrau, where late-stage cases are increasing. High morphological verification rates across all regions ensure reliable and accurate diagnostic data.

Conclusion

The study reveals a significant increase in early-stage breast cancer diagnoses in Kazakhstan, highlighting the effectiveness of the national screening program. However, regional disparities in late-stage cancer incidence suggest a need for targeted interventions and improved regional healthcare.

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哈萨克斯坦乳腺癌的地区分析和分期发病率：综合研究

背景在哈萨克斯坦，乳腺癌是发病率最高的肿瘤病症，位居女性癌症相关死亡原因的前三位。本研究旨在分析哈萨克斯坦地区乳腺癌的发病率，同时考虑分期、年龄、性别和形态学验证等因素。乳腺癌发病率数据（2005-2019 年）来自全国统一电子健康系统（ICD-10 代码 C50）。人口统计学数据来自国家统计局。统计分析包括年龄标准化、粗略和特定年龄的发病率，并使用线性回归和连接点回归程序进行趋势分析，以评估随时间变化的平均百分比。全国年龄标准化发病率为每 10 万人 40.9 例，年增长率为 +1.96 %。早期（I-II 期）乳腺癌发病率呈上升趋势，尤其是在巴甫洛达尔、北哈萨克斯坦和阿拉木图市。相比之下，晚期（III-IV 期）乳腺癌发病率普遍下降，只有科斯塔奈、北哈萨克斯坦和阿特劳等地区除外，这些地区的晚期病例正在增加。所有地区的高形态学验证率确保了诊断数据的可靠性和准确性。然而，晚期癌症发病率的地区差异表明，有必要采取有针对性的干预措施并改善地区医疗保健。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.