A cognitive function test utilizing eye-tracking technology in virtual reality is useful to distinguish between normal cognition, MCI and mild dementia

Archives of Gerontology and Geriatrics Plus Pub Date : 2024-08-15 DOI:10.1016/j.aggp.2024.100070

Katsuyoshi Mizukami , Masatomo Taguchi , Takashi Kouketsu , Naoki Sato , Yoshiro Tanaka , Masahiko Iwakiri , Yoichiro Nishina , Yuan Ma , Iakov Chernyak , Shintaro Karaki

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Abstract

Aim

This study aimed to verify the usability of our newly developed virtual reality-based cognitive function examination (VR-E) to differentiate mild cognitive impairment (MCI) from normal cognition and mild dementia.

Method

The subjects of analysis were 71 people (26 males and 45 females, aged from 59 to 94), including 31 with normal cognitive function, 26 with MCI, and 14 with mild dementia, according to the Clinical Dementia Rating (CDR). The total score and each cognitive domain (memory, judgement, spatial cognition, calculation, language function) score of VR-E were compared among CDR0, CDR0.5 and CDR1. In addition, for CDR0 vs. CDR0.5 and CDR 0.5 vs. 1, the areas under the curve (ROC) were examined using the total score and each cognitive domain of VR-E.

Results

There were significant differences between the three CDR groups in the VR-E scores as well as each VR-E cognitive domain score. The ROC analysis with an AUC value for the VR-E scores between CDR 0 and 0.5 was 0.71, and between CDR 0.5 and 1 was 0.92. For each VR-E cognitive domain, the ROC analysis with an AUC value between CDR 0 and 0.5 was 0.63 for memory, 0.79 for judgment, 0.70 for spatial cognition, 0.62 for calculation, and 0.57 for language. Between CDR 0.5 and 1, the AUC values were 0.81 for memory, 0.75 for judgment, 0.82 for spatial cognition, 0.88 for calculation, and 0.86 for language.

Conclusion

The results suggest that VR-E is useful for differentiating mild cognitive impairment from normal cognition and early dementia.

查看原文本刊更多论文

利用虚拟现实中的眼动跟踪技术进行认知功能测试，有助于区分正常认知、MCI 和轻度痴呆症

目的本研究旨在验证我们新开发的基于虚拟现实的认知功能检查（VR-E）在区分轻度认知障碍（MCI）与正常认知和轻度痴呆方面的可用性。方法分析对象为 71 人（男 26 人，女 45 人，年龄在 59 至 94 岁之间），其中根据临床痴呆评级（CDR），正常认知功能 31 人，MCI 26 人，轻度痴呆 14 人。在 CDR0、CDR0.5 和 CDR1 之间比较了 VR-E 的总分和每个认知领域（记忆、判断、空间认知、计算、语言功能）的得分。此外，对于 CDR0 与 CDR0.5、CDR0.5 与 CDR1，使用 VR-E 的总分和每个认知域对曲线下面积（ROC）进行了检验。根据 ROC 分析，CDR 0 和 0.5 之间的 VR-E 分数的 AUC 值为 0.71，CDR 0.5 和 1 之间的 AUC 值为 0.92。在每个 VR-E 认知领域，CDR 0 和 0.5 之间的 ROC 分析 AUC 值分别为：记忆 0.63、判断 0.79、空间认知 0.70、计算 0.62 和语言 0.57。在 CDR 0.5 和 1 之间，记忆的 AUC 值为 0.81，判断为 0.75，空间认知为 0.82，计算为 0.88，语言为 0.86。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Archives of Gerontology and Geriatrics Plus

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