MicroRNAs: Tiny biomolecules with soaring impact in regulation of metabolic syndrome

IF 1 Q4 GENETICS & HEREDITY

Gene Reports Pub Date : 2024-11-08 DOI:10.1016/j.genrep.2024.102084

Saheli Bose , Nirmalya Dey

{"title":"MicroRNAs: Tiny biomolecules with soaring impact in regulation of metabolic syndrome","authors":"Saheli Bose , Nirmalya Dey","doi":"10.1016/j.genrep.2024.102084","DOIUrl":null,"url":null,"abstract":"<div><div>Dysregulated physiological pathways are a hallmark of metabolic syndromes and often act as cancer risk factors. MicroRNAs (miRNAs) have become important regulators of many biological processes, including growth, development and metabolism. MicroRNAs often play a dual role in metabolic syndromes and cancer development through the modulation of pathways that affect cell proliferation, energy balance, and cellular stress responses. Obesity, insulin resistance, type 2 Diabetes, cardiovascular diseases, hypertension, dyslipidemia do always remain ‘list toppers’ since the inception of the concept of ‘metabolic syndrome’. Aberrantly expressed miRNAs exhibit to play a pivotal role in disturbed metabolic pathways, chronic inflammation, and oxidative stress rendering people predisposed to these metabolic disorders. MicroRNAs can diagnose and predict outcomes in various pathophysiological instances. Hence, miRNA profiles can act as biomarkers for early illness diagnosis, disease progression, and treatment response. The complex crosstalk between different metabolic pathways may be managed by using miRNAs as therapeutic targets or tools for precision medicine. The current review focuses on elaborating the complex functions played by miRNAs in bridging the gap between the unexplored areas of metabolic syndromes, keeping cancer off this discussion.</div></div>","PeriodicalId":12673,"journal":{"name":"Gene Reports","volume":"37 ","pages":"Article 102084"},"PeriodicalIF":1.0000,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gene Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452014424002073","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}

引用次数: 0

Abstract

Dysregulated physiological pathways are a hallmark of metabolic syndromes and often act as cancer risk factors. MicroRNAs (miRNAs) have become important regulators of many biological processes, including growth, development and metabolism. MicroRNAs often play a dual role in metabolic syndromes and cancer development through the modulation of pathways that affect cell proliferation, energy balance, and cellular stress responses. Obesity, insulin resistance, type 2 Diabetes, cardiovascular diseases, hypertension, dyslipidemia do always remain ‘list toppers’ since the inception of the concept of ‘metabolic syndrome’. Aberrantly expressed miRNAs exhibit to play a pivotal role in disturbed metabolic pathways, chronic inflammation, and oxidative stress rendering people predisposed to these metabolic disorders. MicroRNAs can diagnose and predict outcomes in various pathophysiological instances. Hence, miRNA profiles can act as biomarkers for early illness diagnosis, disease progression, and treatment response. The complex crosstalk between different metabolic pathways may be managed by using miRNAs as therapeutic targets or tools for precision medicine. The current review focuses on elaborating the complex functions played by miRNAs in bridging the gap between the unexplored areas of metabolic syndromes, keeping cancer off this discussion.

查看原文本刊更多论文

微小核糖核酸：微小的生物大分子在调节代谢综合征方面影响巨大

生理途径失调是新陈代谢综合征的标志，通常也是癌症的危险因素。微小 RNA（miRNA）已成为许多生物过程（包括生长、发育和新陈代谢）的重要调节因子。通过调节影响细胞增殖、能量平衡和细胞应激反应的途径，MicroRNA 通常在代谢综合征和癌症发展中扮演双重角色。自 "代谢综合征 "概念提出以来，肥胖、胰岛素抵抗、2 型糖尿病、心血管疾病、高血压、血脂异常始终是 "榜首"。表达异常的 miRNAs 在紊乱的代谢途径、慢性炎症和氧化应激中发挥着关键作用，使人们容易患上这些代谢疾病。微 RNA 可以诊断和预测各种病理生理现象的结果。因此，miRNA 图谱可作为早期疾病诊断、疾病进展和治疗反应的生物标志物。将 miRNAs 作为精准医疗的治疗靶点或工具，可以控制不同代谢途径之间的复杂串扰。本综述重点阐述了 miRNA 在弥合代谢综合征未探索领域之间的鸿沟方面所发挥的复杂功能，并将癌症排除在讨论范围之外。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

7.70%

发文量

246

审稿时长

49 days

期刊介绍： Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.