Value of mean platelet volume for diagnosing esophagitis in children with gastroesophageal reflux disease.

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL

Wiener medizinische Wochenschrift Pub Date : 2024-11-18 DOI:10.1007/s10354-024-01062-8

Azin Gouran, Mohammadreza Esmaeili Dooki, Hossein-Ali Nikbakht, Hassan Mahmoodi, Mohammad Pornasrolah, Maryam Nikpour, Sanaz Mehrabani

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引用次数: 0

Abstract

Background: The prevalence of gastroesophageal reflux disease (GERD) in children is increasing in different societies. This study aims to investigate the value of mean platelet volume (MPV) for diagnosing esophagitis in children with GERD.

Methods: This cross-sectional study conducted at Amirkola Children's Hospital between 2022 and 2023 involved children aged 2 to 16 years diagnosed with GERD. The diagnosis was based on the GSQ-YC and GASP‑Q questionnaires. All patients underwent endoscopy, with a biopsy for pathology and a blood sample for MPV analysis. The data were then analyzed using SPSS software version 22 (IBM Corp., Armonk, NY, USA), with a significance level set at lower than 0.05.

Results: The frequency of esophagitis among 194 participants was 39.7%. The overall sensitivity and specificity of MPV for diagnosing esophagitis in children were 64.63% and 52.14%, respectively (area under the curve [AUC] = 0.59). In terms of gender, the overall sensitivity and specificity of the MPV were 85.00% and 32.65% in boys and 70.27% and 51.47% in girls (AUC = 0.58 and AUC = 0.61, respectively). In terms of age, the overall sensitivity and specificity of MPV in children under 12 years were 52.46% and 62.26% and in children older than 12 years 87.5% and 36.36% (AUC = 0.58 and AUC = 0.55, respectively).

Conclusion: In summary, the results of this study indicate that MPV is not a reliable method for diagnosing esophagitis in children with GERD.

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平均血小板体积对诊断患有胃食管反流病的儿童食管炎的价值。

背景：在不同的社会中，儿童胃食管反流病（GERD）的发病率正在上升。本研究旨在探讨平均血小板体积（MPV）对诊断胃食管反流病儿童食管炎的价值：这项横断面研究于 2022 年至 2023 年期间在 Amirkola 儿童医院进行，涉及确诊为胃食管反流病的 2 至 16 岁儿童。诊断依据是 GSQ-YC 和 GASP-Q 问卷。所有患者都接受了内窥镜检查，并进行了病理活检和血液样本 MPV 分析。然后使用 SPSS 软件 22 版（IBM Corp., Armonk, NY, USA）对数据进行分析，显著性水平设定为低于 0.05：194名参与者中食管炎的发生率为39.7%。MPV 诊断儿童食管炎的总体灵敏度和特异度分别为 64.63% 和 52.14%（曲线下面积 [AUC] = 0.59）。在性别方面，男孩 MPV 的总体灵敏度和特异性分别为 85.00% 和 32.65%，女孩为 70.27% 和 51.47%（AUC = 0.58 和 AUC = 0.61）。就年龄而言，12 岁以下儿童 MPV 的总体灵敏度和特异性分别为 52.46% 和 62.26%，12 岁以上儿童的总体灵敏度和特异性分别为 87.5% 和 36.36%（AUC = 0.58 和 AUC = 0.55）：总之，本研究结果表明，MPV 不是诊断胃食管反流患儿食管炎的可靠方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wiener medizinische Wochenschrift MEDICINE, GENERAL & INTERNAL-

CiteScore

2.50

自引率

0.00%

发文量

期刊介绍： ''From the microscope to clinical application!'', Scientists from all European countries make available their recent research results and practical experience through Wiener Medizinische Wochenschrift, the renowned English- and German-language forum. Both original articles and reviews on a broad spectrum of clinical and preclinical medicine are presented within the successful framework of thematic issues compiled by guest editors. Selected cutting-edge topics, such as dementia, geriatric oncology, Helicobacter pylori and phytomedicine make the journal a mandatory source of information.