Biological Effects and Clinical Application of the Anti-Immunoglobulin E Antibody.

IF 2.5 4区 医学 Q3 ALLERGY
Fan Zhang, Yuan Qian, Jiashun Liao, Chuang Zhou, Wei Ren, Qiuzi Jin
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引用次数: 0

Abstract

Background: Immunoglobulin E (IgE) plays a pivotal role in the pathogenesis of allergic diseases by engaging with FcεRI and FcεRII receptors, triggering allergic responses. The development of anti-IgE antibodies, such as omalizumab, has introduced a targeted approach to allergy treatment by neutralizing free IgE and dampening the allergic cascade.

Summary: This review synthesizes the current understanding of IgE's role in allergic diseases and evaluates the clinical utility of omalizumab. It specifically examines the biological mechanisms underpinning anti-IgE antibodies and their efficacy in treating moderate to severe asthma and chronic spontaneous urticaria (CSU). The paper also explores the potential of omalizumab in managing other allergic conditions and considers the long-term implications of anti-IgE therapy.

Key messages: By summarizing and elucidating the biological mechanisms and clinical applications of anti-IgE antibodies through a review of global literature from the past 5 years, this article aims to establish a theoretical foundation for developing innovative anti-allergic treatment strategies. Omalizumab has demonstrated efficacy in reducing IgE-mediated responses, offering improved clinical outcomes for patients with asthma and CSU, with promising potential in an array of allergic diseases. The long-term safety profile of anti-IgE medications remains an area of active investigation, underscoring the need for ongoing research to refine these therapies and expand their application in allergy management.

抗免疫球蛋白 E 抗体的生物效应和临床应用
免疫球蛋白 E(IgE)在过敏性疾病的发生和发展中起着至关重要的作用。自 1967 年发现 IgE 以来,过敏性炎症性疾病的发病机制逐渐被揭示,从而为抗 IgE 治疗性抗体的开发提供了理论基础,抗 IgE 抗体也成为治疗过敏性疾病的新方法。本文旨在通过研究全球相关文献,特别是近五年来有关奥马珠单抗的文献,总结和阐述抗 IgE 抗体的生物效应机制和临床应用。我们力求为抗过敏治疗新策略的形成奠定理论基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.60
自引率
3.60%
发文量
105
审稿时长
2 months
期刊介绍: ''International Archives of Allergy and Immunology'' provides a forum for basic and clinical research in modern molecular and cellular allergology and immunology. Appearing monthly, the journal publishes original work in the fields of allergy, immunopathology, immunogenetics, immunopharmacology, immunoendocrinology, tumor immunology, mucosal immunity, transplantation and immunology of infectious and connective tissue diseases.
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